Whole-Body [18F]FDG-PET/MRI vs. [18F]FDG-PET/CT in Malignant Melanoma

Dominik Berzaczy, Barbara Fueger, Christoph Hoeller, Alexander R Haug, Anton Staudenherz, Gundula Berzaczy, Michael Weber, Marius E Mayerhoefer

Research output: Journal article (peer-reviewed)Journal article

6 Citations (Scopus)

Abstract

PURPOSE: To assess the diagnostic performance of simultaneous whole-body 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/magnetic resonance imaging (MRI) compared to [18F]FDG PET/x-ray computed tomography (CT) for detection of distant metastatic disease in patients with malignant melanoma.

PROCEDURES: We included patients with malignant melanoma who underwent a single injection [18F]FDG dual-imaging protocol that included whole-body PET/CT and subsequent whole-body PET/MRI for staging or restaging purposes in a prospective setting. Images from both modalities were analyzed by two rater teams for the presence of metastatic lesions. PET/CT-PET/MRI overall agreement as well as region-based accuracies, sensitivities (Se), and specificities (Sp) were computed.

RESULTS: Between July 2014 and December 2018, 22 patients were enrolled. Interrater agreement and overall accuracy (consensus reading) were 78.8 % (95 % CI 71-84.9) and 96.1 % (95 % CI 92.3-98) for PET/MRI and 78 % (70.2-84.3) and 97.4 % (95 % CI 93.7-98.9) for PET/CT, respectively (P = 0.42). PET/MRI reached a region-based Se of 89.1 % (95 % CI 79.4-94.5) and a Sp of 100 %, whereas PET/CT showed a region-based Se of 92.7 % (95 % CI 84-96.9) and a Sp of 100 % for the detection of metastatic disease in malignant melanoma.

CONCLUSIONS: Whole-body [18F]FDG-PET/MRI appears to be comparable to [18F]FDG-PET/CT for lesion detection in patients with malignant melanoma.

Original languageEnglish
Pages (from-to)739-744
Number of pages6
JournalMolecular Imaging and Biology
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Jun 2020

Keywords

  • Female
  • Fluorodeoxyglucose F18/chemistry
  • Humans
  • Magnetic Resonance Imaging/methods
  • Male
  • Melanoma/diagnostic imaging
  • Middle Aged
  • Multimodal Imaging/methods
  • Neoplasm Metastasis
  • Positron Emission Tomography Computed Tomography/methods
  • Positron-Emission Tomography/methods
  • Prospective Studies
  • Radiopharmaceuticals/chemistry
  • Whole Body Imaging/methods

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