Waiting times between examinations with intravascularly administered contrast media: a review of contrast media pharmacokinetics and updated ESUR Contrast Media Safety Committee guidelines

Aart J. van der Molen, Ilona A. Dekkers, Remy W.F. Geenen, Marie France Bellin, Michele Bertolotto, Torkel B. Brismar, Jean Michel Correas, Gertraud Heinz-Peer, Andreas H. Mahnken, Carlo C. Quattrocchi, Alexander Radbruch, Peter Reimer, Giles Roditi, Laura Romanini, Carmen Sebastià, Fulvio Stacul, Olivier Clement*

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

7 Citations (Scopus)

Abstract

The pharmacokinetics of contrast media (CM) will determine how long safe waiting intervals between successive CT or MRI examinations should be. The Contrast Media Safety Committee has reviewed the data on pharmacokinetics of contrast media to suggest safe waiting intervals between successive contrast-enhanced imaging studies in relation to the renal function of the patient. Clinical relevance statement: Consider a waiting time between elective contrast-enhanced CT and (coronary) angiography with successive iodine-based contrast media administrations in patients with normal renal function (eGFR > 60 mL/min/1.73 m2) of optimally 12 h (near complete clearance of the previously administered iodine-based contrast media) and minimally 4 h (if clinical indication requires rapid follow-up). Key Points: • Pharmacokinetics of contrast media will guide safe waiting times between successive administrations. • Safe waiting times increase with increasing renal insufficiency. • Iodine-based contrast media influence MRI signal intensities and gadolinium-based contrast agents influence CT attenuation.

Original languageEnglish
Pages (from-to)2512-2523
Number of pages12
JournalEuropean Radiology
Volume34
Issue number4
DOIs
Publication statusPublished - Apr 2024

Keywords

  • Contrast media
  • Hepatic insufficiency
  • Pharmacokinetics
  • Practice guideline
  • Renal insufficiency

ASJC Scopus subject areas

  • Radiology, Nuclear Medicine and Imaging

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