Ultrahypofractionated radiotherapy for localized prostate cancer with simultaneous boost to the dominant intraprostatic lesion: a plan comparison

Raffaella Cambria*, Delia Ciardo, Alessia Bazani, Floriana Pansini, Elena Rondi, Davide Maestri, Dario Zerini, Giulia Marvaso, Pola Romanelli, Giorgia Timon, Cristiana Fodor, Giuseppe Petralia, Sarah Alessi, Paola Pricolo, Barbara Vischioni, Piero Fossati, Sivia Molinelli, Stefania Russo, Mario Ciocca, Ottavio De CobelliGiuseppe Renne, Roberto Orecchia, Federica Cattani, Barbara A. Jereczek-Fossa

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

5 Citations (Scopus)


Objective: To compare different stereotactic body techniques—intensity-modulated radiotherapy with photons and protons, applied to radiotherapy of prostatic cancer—with simultaneous integrated boost (SIB) on the dominant intraprostatic lesion (DIL). Methods: Ten patients were selected for this planning study. Dosimetric results were compared between volumetric modulated arc therapy, intensity-modulated radiation therapy (IMRT), and intensity-modulated proton therapy both with two (IMPT 2F) and five fields (IMPT 5F) planning while applying the prescription schemes of 7.25 Gy/fraction to the prostate gland and 7.5 Gy/fraction to the DIL in 5 fractions. Results: Comparison of the coverages of the planning target volumes showed that small differences exist. The IMPT-2F-5F techniques allowed higher doses in the targets; conformal indexes resulted similar; homogeneity was better in the photon techniques (2%–5%). Regarding the organs at risk, all the techniques were able to maintain the dose well below the prescribed constraints: in the rectum, the IMPT-2F-5F and IMRT were more efficient in lowering the intermediate doses; in the bladder, the median dose was significantly better in the case of IMPT (2F–5F). In the urethra, the best sparing was achieved only by IMPT-5F. Conclusions: Stereotactic radiotherapy with SIB for localized prostate cancer is feasible with all the investigated techniques. Concerning IMPT, the two-beam technique does not seem to have a greater advantage compared to the standard techniques; the 5-beam technique seems more promising also accounting for the range uncertainty.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
Issue number3
Publication statusPublished - Jun 2022
Externally publishedYes


  • dominant intraprostatic lesion
  • IMPT
  • Prostate cancer
  • proton therapy
  • SBRT
  • stereotactic body radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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