Tree nut allergens

Sabine Geiselhart, Karin Hoffmann-Sommergruber*, Merima Bublin

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Review article

70 Citations (Scopus)

Abstract

Tree nuts are considered as part of a healthy diet due to their high nutritional quality. However, they are also a potent source of allergenic proteins inducing IgE mediated hypersensitivity often causing serious, life-threatening reactions. The reported prevalence of tree nut allergy is up to 4.9% worldwide. The general term “tree nuts” comprises a number of nuts, seeds, and drupes, derived from trees from different botanical families. For hazelnut and walnut several allergens have been identified which are already partly applied in component resolved diagnosis, while for other tree nuts such as macadamia, coconut, and Brazil nut only individual allergens were identified and data on additional allergenic proteins are missing. This review summarizes the current knowledge on tree nut allergens and describes their physicochemical and immunological characterization and clinical relevance.

Original languageEnglish
Pages (from-to)71-81
Number of pages11
JournalMolecular Immunology
Volume100
DOIs
Publication statusPublished - 2018
Externally publishedYes

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