TY - JOUR
T1 - Transbronchial lung cryobiopsy
T2 - prospective safety evaluation and 90-day mortality after a standardized examination protocol
AU - Hackner, Klaus
AU - Stadler, Antonia
AU - Schragel, Felix
AU - Klamminger, Valerie
AU - Ghanim, Bahil
AU - Varga, Alexander
AU - Errhalt, Peter
N1 - Publisher Copyright:
© The Author(s), 2022.
PY - 2022/3/4
Y1 - 2022/3/4
N2 - BACKGROUND: Transbronchial lung cryobiopsy (TBLC) is a new method of bronchoscopic tissue sampling in patients with unclear diffuse parenchymal lung disease (DPLD). While not the gold standard, TBLC has a good diagnostic correlation with surgical lung biopsy, and retrospective analyses of peri-interventional complications and mortality are promising. However, prospective reports on 90-day mortality are lacking.OBJECTIVES: This study addresses morbidity and 30- and 90-day mortality in TBLC after a standardized protocol.METHODS: In this prospective study, 75 patients with DPLD requiring tissue sampling were included. A standardized protocol (including prophylactic use of an endobronchial balloon, postinterventional observation, and minimum sampling requirements) was used in all patients. Adverse events (pneumothorax, bronchial bleeding, premature discontinuation, prolonged monitoring at ICU, and fatal outcome) and 30- and 90-day mortality rates were recorded.RESULTS: A total of 308 cryobiopsies were performed in 75 patients. Peri- and postinterventional pneumothorax were observed in 20% (9.3% mild and 10.7% moderate with the necessity of chest drainage), and bronchial bleeding was found in 29.3% (22.7% moderate and 6.7% severe). Total lung capacity below normal value was associated with the risk of pneumothorax (p = 0.009), and diffusion limitation for carbon monoxide below normal value was associated with the risk of bronchial bleeding (p = 0.044). No fatal events were observed within 30 days, and the 90-day mortality rate was 1.3%, but not related to the procedure itself.CONCLUSION: As it gradually becomes the invasive procedure of choice in unclear DPLD, TBLC is a safe procedure with a low 30- and 90-day mortality.Trial registration ID: DRKS00026746 (German Clinical Trial Register).
AB - BACKGROUND: Transbronchial lung cryobiopsy (TBLC) is a new method of bronchoscopic tissue sampling in patients with unclear diffuse parenchymal lung disease (DPLD). While not the gold standard, TBLC has a good diagnostic correlation with surgical lung biopsy, and retrospective analyses of peri-interventional complications and mortality are promising. However, prospective reports on 90-day mortality are lacking.OBJECTIVES: This study addresses morbidity and 30- and 90-day mortality in TBLC after a standardized protocol.METHODS: In this prospective study, 75 patients with DPLD requiring tissue sampling were included. A standardized protocol (including prophylactic use of an endobronchial balloon, postinterventional observation, and minimum sampling requirements) was used in all patients. Adverse events (pneumothorax, bronchial bleeding, premature discontinuation, prolonged monitoring at ICU, and fatal outcome) and 30- and 90-day mortality rates were recorded.RESULTS: A total of 308 cryobiopsies were performed in 75 patients. Peri- and postinterventional pneumothorax were observed in 20% (9.3% mild and 10.7% moderate with the necessity of chest drainage), and bronchial bleeding was found in 29.3% (22.7% moderate and 6.7% severe). Total lung capacity below normal value was associated with the risk of pneumothorax (p = 0.009), and diffusion limitation for carbon monoxide below normal value was associated with the risk of bronchial bleeding (p = 0.044). No fatal events were observed within 30 days, and the 90-day mortality rate was 1.3%, but not related to the procedure itself.CONCLUSION: As it gradually becomes the invasive procedure of choice in unclear DPLD, TBLC is a safe procedure with a low 30- and 90-day mortality.Trial registration ID: DRKS00026746 (German Clinical Trial Register).
KW - Bronchoscopy/adverse effects
KW - Humans
KW - Lung/pathology
KW - Lung Diseases, Interstitial/etiology
KW - Prospective Studies
KW - Retrospective Studies
UR - http://www.scopus.com/inward/record.url?scp=85125613425&partnerID=8YFLogxK
U2 - 10.1177/17534666221077562
DO - 10.1177/17534666221077562
M3 - Journal article
C2 - 35238279
SN - 1753-4658
VL - 16
SP - 17534666221077562
JO - Therapeutic Advances in Respiratory Disease
JF - Therapeutic Advances in Respiratory Disease
ER -