Toward a common interpretation of the 3Rs principles in animal research

Jan Lauwereyns; Jeffrey Bajramovic; Bettina Bert; Samuel Camenzind; Joery De Kock; Alisa Elezović; Sevilay Erden; Fernando Gonzalez-Uarquin; Yesim Isil Ulman; Orsolya Ivett Hoffmann; Maria Kitsara; Nikolaos Kostomitsopoulos; Winfried Neuhaus; Benoit Petit-Demouliere; Simone Pollo; Brígida Riso; Sophie Schober; Athanassia Sotiropoulos; Aurélie Thomas; Augusto Vitale; Doris Wilflingseder; Arti Ahluwalia

doi:10.1038/s41684-024-01476-2

Toward a common interpretation of the 3Rs principles in animal research

Jan Lauwereyns, Jeffrey Bajramovic, Bettina Bert, Samuel Camenzind, Joery De Kock, Alisa Elezović, Sevilay Erden, Fernando Gonzalez-Uarquin, Yesim Isil Ulman, Orsolya Ivett Hoffmann, Maria Kitsara, Nikolaos Kostomitsopoulos, Winfried Neuhaus, Benoit Petit-Demouliere, Simone Pollo, Brígida Riso, Sophie Schober, Athanassia Sotiropoulos, Aurélie Thomas, Augusto VitaleDoris Wilflingseder, Arti Ahluwalia

Research output: Journal article (peer-reviewed) › Journal article

Abstract

Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts.

Original language	English
Journal	Lab Animal
DOIs	https://doi.org/10.1038/s41684-024-01476-2
Publication status	E-pub ahead of print - 15 Nov 2024

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Lauwereyns, J., Bajramovic, J., Bert, B., Camenzind, S., De Kock, J., Elezović, A., Erden, S., Gonzalez-Uarquin, F., Ulman, Y. I., Hoffmann, O. I., Kitsara, M., Kostomitsopoulos, N., Neuhaus, W., Petit-Demouliere, B., Pollo, S., Riso, B., Schober, S., Sotiropoulos, A., Thomas, A., ... Ahluwalia, A. (2024). Toward a common interpretation of the 3Rs principles in animal research. Lab Animal. Advance online publication. https://doi.org/10.1038/s41684-024-01476-2

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title = "Toward a common interpretation of the 3Rs principles in animal research",

abstract = "Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts.",

author = "Jan Lauwereyns and Jeffrey Bajramovic and Bettina Bert and Samuel Camenzind and {De Kock}, Joery and Alisa Elezovi{\'c} and Sevilay Erden and Fernando Gonzalez-Uarquin and Ulman, {Yesim Isil} and Hoffmann, {Orsolya Ivett} and Maria Kitsara and Nikolaos Kostomitsopoulos and Winfried Neuhaus and Benoit Petit-Demouliere and Simone Pollo and Br{\'i}gida Riso and Sophie Schober and Athanassia Sotiropoulos and Aur{\'e}lie Thomas and Augusto Vitale and Doris Wilflingseder and Arti Ahluwalia",

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doi = "10.1038/s41684-024-01476-2",

language = "English",

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Lauwereyns, J, Bajramovic, J, Bert, B, Camenzind, S, De Kock, J, Elezović, A, Erden, S, Gonzalez-Uarquin, F, Ulman, YI, Hoffmann, OI, Kitsara, M, Kostomitsopoulos, N, Neuhaus, W, Petit-Demouliere, B, Pollo, S, Riso, B, Schober, S, Sotiropoulos, A, Thomas, A, Vitale, A, Wilflingseder, D & Ahluwalia, A 2024, 'Toward a common interpretation of the 3Rs principles in animal research', Lab Animal. https://doi.org/10.1038/s41684-024-01476-2

TY - JOUR

T1 - Toward a common interpretation of the 3Rs principles in animal research

AU - Lauwereyns, Jan

AU - Bajramovic, Jeffrey

AU - Bert, Bettina

AU - Camenzind, Samuel

AU - De Kock, Joery

AU - Elezović, Alisa

AU - Erden, Sevilay

AU - Gonzalez-Uarquin, Fernando

AU - Ulman, Yesim Isil

AU - Hoffmann, Orsolya Ivett

AU - Kitsara, Maria

AU - Kostomitsopoulos, Nikolaos

AU - Neuhaus, Winfried

AU - Petit-Demouliere, Benoit

AU - Pollo, Simone

AU - Riso, Brígida

AU - Schober, Sophie

AU - Sotiropoulos, Athanassia

AU - Thomas, Aurélie

AU - Vitale, Augusto

AU - Wilflingseder, Doris

AU - Ahluwalia, Arti

PY - 2024/11/15

Y1 - 2024/11/15

N2 - Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts.

AB - Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts.

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U2 - 10.1038/s41684-024-01476-2

DO - 10.1038/s41684-024-01476-2

M3 - Journal article

C2 - 39548348

SN - 0093-7355

JO - Lab Animal

JF - Lab Animal

ER -

Toward a common interpretation of the 3Rs principles in animal research

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