@article{1c7e175eea4e432ba63d459e98ac17a1,
title = "The molecular mechanisms mediating class II PI 3-kinase function in cell physiology",
abstract = "The phosphoinositide 3-kinase (PI3K) family of lipid-modifying enzymes plays vital roles in cell signaling and membrane trafficking through the production of 3-phosphorylated phosphoinositides. Numerous studies have analyzed the structure and function of class I and class III PI3Ks. In contrast, we know comparably little about the structure and physiological functions of the class II enzymes. Only recent studies have begun to unravel their roles in development, endocytic and endolysosomal membrane dynamics, signal transduction, and cell migration, while the mechanisms that control their localization and enzymatic activity remain largely unknown. Here, we summarize our current knowledge of the class II PI3Ks and outline open questions related to their structure, enzymatic activity, and their physiological and pathophysiological functions.",
keywords = "Animals, Cell Movement, Humans, Insulin-Secreting Cells/metabolism, Phosphatidylinositol 3-Kinases/metabolism, Signal Transduction",
author = "Koch, {Philipp Alexander} and Dornan, {Gillian Leigh} and Manuel Hessenberger and Volker Haucke",
note = "Funding Information: Work in the authors' laboratory is supported by grants from the Deutsche Forschungsgemeinschaft (DFG; HA2686/15-1 and TRR186/A08). PAK was the recipient of a predoctoral fellowship from the Sonnenfeld Foundation (Berlin, Germany), and MH acknowledges generous support by a Schr{\"o}dinger Fellowship from the Fonds f{\"u}r Wissenschaftliche Forschung (FWF, Austria). GLD received a Banting Postdoctoral Fellowship from the Canadian Institutes of Health Research (CIHR) and is currently supported by a Marie Sk{\l}odowska-Curie Individual Fellowship from the European Union (EU, Horizon 2020). Funding Information: Work in the authors' laboratory is supported by grants from the Deutsche Forschungsgemeinschaft (DFG; HA2686/15‐1 and TRR186/A08). PAK was the recipient of a predoctoral fellowship from the Sonnenfeld Foundation (Berlin, Germany), and MH acknowledges generous support by a Schr{\"o}dinger Fellowship from the Fonds f{\"u}r Wissenschaftliche Forschung (FWF, Austria). GLD received a Banting Postdoctoral Fellowship from the Canadian Institutes of Health Research (CIHR) and is currently supported by a Marie Sk{\l}odowska‐Curie Individual Fellowship from the European Union (EU, Horizon 2020). Publisher Copyright: {\textcopyright} 2021 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.",
year = "2021",
month = dec,
doi = "10.1111/febs.15692",
language = "English",
volume = "288",
pages = "7025--7042",
journal = "FEBS Journal",
issn = "1742-464X",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "24",
}