Sex-Related Factors in Valvular Heart Disease: JACC Focus Seminar 5/7

Rebecca T Hahn, Marie-Annick Clavel, Julia Mascherbauer, Stephanie L Mick, Anita W Asgar, Pamela S Douglas

Research output: Journal article (peer-reviewed)Review article

16 Citations (Scopus)


Numerous sex-based differences are observed across the spectrum of valvular heart disease, starting with pathophysiology and progression of disease, moving on to compensation and comorbidities (both cardiovascular such as coronary artery disease and noncardiovascular such as frailty), assessment of severity and hemodynamics including timing of intervention, and procedural risks/benefits and outcomes. The aortic valve is perhaps best understood with sex differences in both pathologic changes and response to volume and pressure overload, yet large gaps in our understanding still exist. Studies of other valve diseases have focused on differences in prevalence, presentation, and outcomes for surgical or transcatheter therapies. Defining sex-specific responses to valvular heart disease may improve disease recognition, define treatment strategies, and improve outcomes.

Original languageEnglish
Pages (from-to)1506-1518
Number of pages13
JournalJournal of the American College of Cardiology
Issue number15
Publication statusPublished - 19 Apr 2022


  • Aortic Valve/surgery
  • Female
  • Heart Valve Diseases/surgery
  • Heart Valve Prosthesis Implantation
  • Hemodynamics
  • Humans
  • Male
  • Sex Factors


Dive into the research topics of 'Sex-Related Factors in Valvular Heart Disease: JACC Focus Seminar 5/7'. Together they form a unique fingerprint.

Cite this