Risk factors predicting prognosis and outcome of elderly patients with isolated traumatic brain injury

Roman C Ostermann, Julian Joestl, Thomas M Tiefenboeck, Nikolaus Lang, Patrick Platzer, Marcus Hofbauer

Research output: Journal article (peer-reviewed)Journal article

27 Citations (Scopus)


BACKGROUND: Traumatic brain injury (TBI), particularly in the elderly patient population, is known to be the single largest cause of death and disability worldwide. The purpose of this retrospective study was to evaluate clinical factors predicting poor outcome with special emphasis on the impact of respiratory failure (RF) on mortality in elderly patients with isolated severe TBI.

METHODS: All elderly patients (age ≥ 65 years) with isolated severe head injury, admitted to this level I trauma center, during a period of 18 years (from January 1992 to December 2010) were identified from the trauma registry. The medical records were reviewed for demographics, mechanism of injury (MOI), GCS score at admission, RF, pupillary light reflex (LR), CT findings (subdural hematoma, subarachnoid hematoma, edema, midline-shift), and whether there was conservative treatment or surgical intervention and the Glasgow Outcome Score (GOS) at hospital discharge. Stepwise logistic regression analysis was used to identify risk factors for a poor prognosis and outcome.

RESULTS: The following variables influenced the mortality: respiratory failure, pupillary response, and the injury severity score (ISS). A significant increased risk of death was also found for patients with a midline shift of over 15 mm.

CONCLUSIONS: The present study predicts a strong correlation between respiratory failure, pathological pupillary response, a higher ISS, and substantial midline shift with poor outcomes in elderly patients sustaining an isolated severe TBI.

TRIAL REGISTRATION: Clinical trials: ID: NCT02386865 . Registered 12 March 2015-retrospectively registered.

Original languageEnglish
Article number277
Pages (from-to)277
JournalJournal of Orthopaedic Surgery and Research
Issue number1
Publication statusPublished - 03 Nov 2018


  • Aged
  • Aged, 80 and over
  • Austria/epidemiology
  • Brain Injuries, Traumatic/complications
  • Emergency Treatment
  • Female
  • Humans
  • Male
  • Prognosis
  • Respiratory Insufficiency/etiology
  • Retrospective Studies
  • Risk Factors
  • Isolated severe traumatic brain injuries (TBI)
  • Outcome prediction
  • Elderly patients
  • Respiratory failure

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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