Retinal imaging with optical coherence tomography in multiple sclerosis: novel aspects

Research output: Journal article (peer-reviewed)Review article

3 Citations (Scopus)


Optical coherence tomography (OCT) is of increasing interest in the clinical assessment of multiple sclerosis (MS) patients beyond the scope of clinical studies. In this narrative review, we discuss novel changes of OCT parameters during acute optic neuritis and the disease course of MS patients. OCT images document the changes of retinal layers during an episode of acute optic neuritis and can therefore provide valuable insights into the pathophysiology. Moreover, MS patients show progredient thinning of retinal layers throughout the disease. The thinning is accelerated through relapses as well as disease progression without relapse. The OCT parameters are also associated with clinical outcome parameters, including disability, cognitive function, and brain atrophy. The impact of disease-modifying therapies on OCT parameters is the subject of ongoing research and depends on the agent used. Additional data are still necessary before OCT parameters can be implemented in the clinical standard of care of MS patients.

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalWiener Medizinische Wochenschrift
Issue number15-16
Early online date28 Mar 2022
Publication statusPublished - Nov 2022


  • Disease Progression
  • Humans
  • Multiple Sclerosis/diagnostic imaging
  • Optic Neuritis/diagnostic imaging
  • Retina/diagnostic imaging
  • Tomography, Optical Coherence/methods

ASJC Scopus subject areas

  • General Medicine


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