Abstract
OBJECTIVE: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.
METHOD: We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.
RESULTS: Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.
CONCLUSION: Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.
| Original language | English |
|---|---|
| Pages (from-to) | 260-264 |
| Number of pages | 5 |
| Journal | Neuropsychobiology |
| Volume | 43 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
Keywords
- Adult
- Cerebrovascular Circulation/physiology
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Radiopharmaceuticals
- Stress Disorders, Post-Traumatic/diagnostic imaging
- Technetium Tc 99m Exametazime
- Tomography, Emission-Computed, Single-Photon
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