Regional cerebral blood flow in patients suffering from post-traumatic stress disorder

S Mirzaei, P Knoll, A Keck, B Preitler, E Gutierrez, H Umek, H Köhn, M Pecherstorfer

Research output: Journal article (peer-reviewed)Journal article

30 Citations (Scopus)


OBJECTIVE: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.

METHOD: We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.

RESULTS: Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.

CONCLUSION: Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.

Original languageEnglish
Pages (from-to)260-264
Number of pages5
Issue number4
Publication statusPublished - 2001
Externally publishedYes


  • Adult
  • Cerebrovascular Circulation/physiology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Radiopharmaceuticals
  • Stress Disorders, Post-Traumatic/diagnostic imaging
  • Technetium Tc 99m Exametazime
  • Tomography, Emission-Computed, Single-Photon


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