Regional cerebral blood flow in patients suffering from post-traumatic stress disorder

S Mirzaei; P Knoll; A Keck; B Preitler; E Gutierrez; H Umek; H Köhn; M Pecherstorfer

doi:10.1159/000054900

Regional cerebral blood flow in patients suffering from post-traumatic stress disorder

S Mirzaei, P Knoll, A Keck, B Preitler, E Gutierrez, H Umek, H Köhn, M Pecherstorfer

Research output: Journal article (peer-reviewed) › Journal article

30 Citations (Scopus)

Abstract

OBJECTIVE: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.

METHOD: We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.

RESULTS: Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.

CONCLUSION: Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.

Original language	English
Pages (from-to)	260-264
Number of pages	5
Journal	Neuropsychobiology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1159/000054900
Publication status	Published - 2001
Externally published	Yes

Keywords

Adult
Cerebrovascular Circulation/physiology
Female
Humans
Magnetic Resonance Imaging
Male
Radiopharmaceuticals
Stress Disorders, Post-Traumatic/diagnostic imaging
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon

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10.1159/000054900

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title = "Regional cerebral blood flow in patients suffering from post-traumatic stress disorder",

abstract = "OBJECTIVE: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.METHOD: We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.RESULTS: Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.CONCLUSION: Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.",

keywords = "Adult, Cerebrovascular Circulation/physiology, Female, Humans, Magnetic Resonance Imaging, Male, Radiopharmaceuticals, Stress Disorders, Post-Traumatic/diagnostic imaging, Technetium Tc 99m Exametazime, Tomography, Emission-Computed, Single-Photon",

author = "S Mirzaei and P Knoll and A Keck and B Preitler and E Gutierrez and H Umek and H K{\"o}hn and M Pecherstorfer",

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doi = "10.1159/000054900",

language = "English",

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AU - Mirzaei, S

AU - Knoll, P

AU - Keck, A

AU - Preitler, B

AU - Gutierrez, E

AU - Umek, H

AU - Köhn, H

AU - Pecherstorfer, M

PY - 2001

Y1 - 2001

N2 - OBJECTIVE: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.METHOD: We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.RESULTS: Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.CONCLUSION: Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.

AB - OBJECTIVE: The aim of the study was to determine whether regional cerebral blood flow in survivors of torture suffering from post-traumatic stress disorder (PTSD) differed significantly from that in healthy controls.METHOD: We examined the cerebral regional distribution of 99m-technetium-hexamethylpropyleneamineoxime (HMPAO) using single photon emission computed tomography (SPECT) in 8 patients and in 8 healthy controls. A semi-quantitative analysis was performed in which symmetrical regions of interest (ROI) were drawn in all subjects.RESULTS: Regional blood flow was markedly more heterogeneous in patients suffering from PTSD than in healthy controls. The differences are significant.CONCLUSION: Severe psychological trauma induced by torture can cause neurobiologic alterations that may contribute, even years after the original trauma, to a number of complaints commonly expressed by patients suffering from PTSD.

KW - Adult

KW - Cerebrovascular Circulation/physiology

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Radiopharmaceuticals

KW - Stress Disorders, Post-Traumatic/diagnostic imaging

KW - Technetium Tc 99m Exametazime

KW - Tomography, Emission-Computed, Single-Photon

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DO - 10.1159/000054900

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VL - 43

SP - 260

EP - 264

JO - Neuropsychobiology

JF - Neuropsychobiology

IS - 4

ER -

Regional cerebral blood flow in patients suffering from post-traumatic stress disorder

Abstract

Keywords

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