Recent developments and highlights in mechanisms of allergic diseases: Microbiome

Nonhlanhla Lunjani, Pattraporn Satitsuksanoa, Zuzanna Lukasik, Milena Sokolowska, Thomas Eiwegger, Liam O'Mahony

Research output: Journal article (peer-reviewed)Review article

Abstract

All body surfaces are exposed to a wide variety of microbes, which significantly influence immune reactivity within the host. This review provides an update on some of the critical novel findings that have been published on the influence of the microbiome on atopic dermatitis, food allergy and asthma. Microbial dysbiosis has consistently been observed in the skin, gut and lungs of patients with atopic dermatitis, food allergy and asthma, respectively, and the role of specific microbes in allergic disorders is being intensively investigated. However, many of these discoveries have yet to be translated into routine clinical practice.

Original languageEnglish
Pages (from-to)2314-2327
Number of pages14
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume73
Issue number12
DOIs
Publication statusPublished - Dec 2018
Externally publishedYes

Keywords

  • Asthma/microbiology
  • Dermatitis, Atopic/microbiology
  • Dysbiosis
  • Food Hypersensitivity/microbiology
  • Humans
  • Hypersensitivity/microbiology
  • Microbiota/immunology

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