Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study

Larissa Nixdorf; Lukas Hartl; Stefanie Ströhl; Daniel Moritz Felsenreich; Magdalena Mairinger; Julia Jedamzik; Paula Richwien; Behrang Mozayani; Georg Semmler; Lorenz Balcar; Michael Schwarz; Mathias Jachs; Nina Dominik; Christoph Bichler; Michael Trauner; Mattias Mandorfer; Thomas Reiberger; Felix B Langer; David Josef Maria Bauer; Gerhard Prager

doi:10.1038/s41598-024-67415-w

Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study

Larissa Nixdorf, Lukas Hartl, Stefanie Ströhl, Daniel Moritz Felsenreich, Magdalena Mairinger, Julia Jedamzik, Paula Richwien, Behrang Mozayani, Georg Semmler, Lorenz Balcar, Michael Schwarz, Mathias Jachs, Nina Dominik, Christoph Bichler, Michael Trauner, Mattias Mandorfer, Thomas Reiberger, Felix B Langer, David Josef Maria Bauer, Gerhard Prager

Research output: Journal article (peer-reviewed) › Journal article

9 Citations (Scopus)

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) and related steatohepatitis (MASH) are common among obese patients and may improve after metabolic/bariatric surgery (MBS). 93 Patients undergoing MBS in 2021-2022 were prospectively enrolled. Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastography) and non-invasive steatosis assessment (via controlled attenuation parameter [CAP]) were performed before (baseline [BL]) and three months (M3) after surgery. 93 patients (median age 40.9 years, 68.8% female, median BL-BMI: 46.0 kg/m2) were included. BL-liver biopsy showed MASLD in 82.8% and MASH in 34.4% of patients. At M3 the median relative total weight loss (%TWL) was 20.1% and the median BMI was 36.1 kg/m2. LSM assessed by VCTE and 2DSWE, as well as median CAP all decreased significantly from BL to M3 both in the overall cohort and among patients with MASH. There was a decrease from BL to M3 in median levels of ALT (34.0 U/L to 31 U/L; p = 0.025), gamma glutamyl transferase (BL: 30.0 to 21.0 U/L; p < 0.001) and MASLD fibrosis score (BL: - 0.97 to - 1.74; p < 0.001). Decreasing LSM and CAP, as well as liver injury markers suggest an improvement of MASLD/MASH as early as 3 months after MBS.

Original language	English
Article number	17558
Pages (from-to)	17558
Journal	Scientific Reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-024-67415-w
Publication status	Published - Dec 2024
Externally published	Yes

Keywords

Fatty Liver/complications
Liver/pathology
Bariatric Surgery/methods
Prospective Studies
Elasticity Imaging Techniques
Body Mass Index
Humans
Male
Female
Adult
Middle Aged
Obesity/complications
Treatment Outcome

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10.1038/s41598-024-67415-w

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Nixdorf, L., Hartl, L., Ströhl, S., Felsenreich, D. M., Mairinger, M., Jedamzik, J., Richwien, P., Mozayani, B., Semmler, G., Balcar, L., Schwarz, M., Jachs, M., Dominik, N., Bichler, C., Trauner, M., Mandorfer, M., Reiberger, T., Langer, F. B., Bauer, D. J. M., & Prager, G. (2024). Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study. Scientific Reports, 14(1), 17558. Article 17558. https://doi.org/10.1038/s41598-024-67415-w

@article{c4a208df768241558bea21774d387308,

title = "Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study",

abstract = "Metabolic dysfunction-associated steatotic liver disease (MASLD) and related steatohepatitis (MASH) are common among obese patients and may improve after metabolic/bariatric surgery (MBS). 93 Patients undergoing MBS in 2021-2022 were prospectively enrolled. Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastography) and non-invasive steatosis assessment (via controlled attenuation parameter [CAP]) were performed before (baseline [BL]) and three months (M3) after surgery. 93 patients (median age 40.9 years, 68.8\% female, median BL-BMI: 46.0 kg/m2) were included. BL-liver biopsy showed MASLD in 82.8\% and MASH in 34.4\% of patients. At M3 the median relative total weight loss (\%TWL) was 20.1\% and the median BMI was 36.1 kg/m2. LSM assessed by VCTE and 2DSWE, as well as median CAP all decreased significantly from BL to M3 both in the overall cohort and among patients with MASH. There was a decrease from BL to M3 in median levels of ALT (34.0 U/L to 31 U/L; p = 0.025), gamma glutamyl transferase (BL: 30.0 to 21.0 U/L; p < 0.001) and MASLD fibrosis score (BL: - 0.97 to - 1.74; p < 0.001). Decreasing LSM and CAP, as well as liver injury markers suggest an improvement of MASLD/MASH as early as 3 months after MBS.",

keywords = "Fatty Liver/complications, Liver/pathology, Bariatric Surgery/methods, Prospective Studies, Elasticity Imaging Techniques, Body Mass Index, Humans, Male, Female, Adult, Middle Aged, Obesity/complications, Treatment Outcome",

author = "Larissa Nixdorf and Lukas Hartl and Stefanie Str{\"o}hl and Felsenreich, \{Daniel Moritz\} and Magdalena Mairinger and Julia Jedamzik and Paula Richwien and Behrang Mozayani and Georg Semmler and Lorenz Balcar and Michael Schwarz and Mathias Jachs and Nina Dominik and Christoph Bichler and Michael Trauner and Mattias Mandorfer and Thomas Reiberger and Langer, \{Felix B\} and Bauer, \{David Josef Maria\} and Gerhard Prager",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = dec,

doi = "10.1038/s41598-024-67415-w",

language = "English",

volume = "14",

pages = "17558",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

Nixdorf, L, Hartl, L, Ströhl, S, Felsenreich, DM, Mairinger, M, Jedamzik, J, Richwien, P, Mozayani, B, Semmler, G, Balcar, L, Schwarz, M, Jachs, M, Dominik, N, Bichler, C, Trauner, M, Mandorfer, M, Reiberger, T, Langer, FB, Bauer, DJM & Prager, G 2024, 'Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study', Scientific Reports, vol. 14, no. 1, 17558, pp. 17558. https://doi.org/10.1038/s41598-024-67415-w

TY - JOUR

T1 - Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery

T2 - a prospective study

AU - Nixdorf, Larissa

AU - Hartl, Lukas

AU - Ströhl, Stefanie

AU - Felsenreich, Daniel Moritz

AU - Mairinger, Magdalena

AU - Jedamzik, Julia

AU - Richwien, Paula

AU - Mozayani, Behrang

AU - Semmler, Georg

AU - Balcar, Lorenz

AU - Schwarz, Michael

AU - Jachs, Mathias

AU - Dominik, Nina

AU - Bichler, Christoph

AU - Trauner, Michael

AU - Mandorfer, Mattias

AU - Reiberger, Thomas

AU - Langer, Felix B

AU - Bauer, David Josef Maria

AU - Prager, Gerhard

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/12

Y1 - 2024/12

N2 - Metabolic dysfunction-associated steatotic liver disease (MASLD) and related steatohepatitis (MASH) are common among obese patients and may improve after metabolic/bariatric surgery (MBS). 93 Patients undergoing MBS in 2021-2022 were prospectively enrolled. Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastography) and non-invasive steatosis assessment (via controlled attenuation parameter [CAP]) were performed before (baseline [BL]) and three months (M3) after surgery. 93 patients (median age 40.9 years, 68.8% female, median BL-BMI: 46.0 kg/m2) were included. BL-liver biopsy showed MASLD in 82.8% and MASH in 34.4% of patients. At M3 the median relative total weight loss (%TWL) was 20.1% and the median BMI was 36.1 kg/m2. LSM assessed by VCTE and 2DSWE, as well as median CAP all decreased significantly from BL to M3 both in the overall cohort and among patients with MASH. There was a decrease from BL to M3 in median levels of ALT (34.0 U/L to 31 U/L; p = 0.025), gamma glutamyl transferase (BL: 30.0 to 21.0 U/L; p < 0.001) and MASLD fibrosis score (BL: - 0.97 to - 1.74; p < 0.001). Decreasing LSM and CAP, as well as liver injury markers suggest an improvement of MASLD/MASH as early as 3 months after MBS.

AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) and related steatohepatitis (MASH) are common among obese patients and may improve after metabolic/bariatric surgery (MBS). 93 Patients undergoing MBS in 2021-2022 were prospectively enrolled. Liver stiffness measurement (LSM; via vibration-controlled transient elastography [VCTE], point [pSWE] and 2D [2DSWE] shear wave elastography) and non-invasive steatosis assessment (via controlled attenuation parameter [CAP]) were performed before (baseline [BL]) and three months (M3) after surgery. 93 patients (median age 40.9 years, 68.8% female, median BL-BMI: 46.0 kg/m2) were included. BL-liver biopsy showed MASLD in 82.8% and MASH in 34.4% of patients. At M3 the median relative total weight loss (%TWL) was 20.1% and the median BMI was 36.1 kg/m2. LSM assessed by VCTE and 2DSWE, as well as median CAP all decreased significantly from BL to M3 both in the overall cohort and among patients with MASH. There was a decrease from BL to M3 in median levels of ALT (34.0 U/L to 31 U/L; p = 0.025), gamma glutamyl transferase (BL: 30.0 to 21.0 U/L; p < 0.001) and MASLD fibrosis score (BL: - 0.97 to - 1.74; p < 0.001). Decreasing LSM and CAP, as well as liver injury markers suggest an improvement of MASLD/MASH as early as 3 months after MBS.

KW - Fatty Liver/complications

KW - Liver/pathology

KW - Bariatric Surgery/methods

KW - Prospective Studies

KW - Elasticity Imaging Techniques

KW - Body Mass Index

KW - Humans

KW - Male

KW - Female

KW - Adult

KW - Middle Aged

KW - Obesity/complications

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/85200194289

U2 - 10.1038/s41598-024-67415-w

DO - 10.1038/s41598-024-67415-w

M3 - Journal article

C2 - 39080285

SN - 2045-2322

VL - 14

SP - 17558

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 17558

ER -

Rapid improvement of hepatic steatosis and liver stiffness after metabolic/bariatric surgery: a prospective study

Abstract

Keywords

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