Pupillometry examinations of the human eye with the eye diagnostic device PEP-2000-First results

Nikola Schieding, Thomas Reuter*, Andreas Grundmann, Sebastian Walther, Sascha Klee

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article


Pupillometry forms the diagnostic basis for numerous pathologies of the eye. For this reason, fast and accurate diagnostics in the field of ophthalmology are essential. Two examination techniques, full-field ERG and pupillometry were combined in a diagnostic device developed by ICM e.V. to reduce the examination process for both examiners and patients. In this paper, the device is examined for the quality of the pupillometry measurements. A study with 12 healthy subjects (3 f, 9 m, 36.33 ± 11.94 years) was conducted to evaluate the device. The results showed that the minimal pupil diameter is 40 % higher than the literature values. The main reason for the differences is the low light intensity of 15 cd/m2. However, the maximum pupil diameter is within the range of the researched values. The results of the pupillary reaction measurements show that the values obtained (amplitude, contraction time and peak time) are within the range of literature values. The latency time of 690 ms is 40 % too high. The reason for this could be the moderate pupil detection rate of 50-70 %. Nevertheless, plausible and comparable analysis values could be obtained with the eye diagnostic device PEP-2000. Further work will look at improving pupil detection rates.

Original languageEnglish
Pages (from-to)648-651
Number of pages4
JournalCurrent Directions in Biomedical Engineering
Issue number2
Publication statusPublished - 01 Aug 2022


  • Human eye
  • Ophthalmology
  • Pupil diameter
  • Pupillary reaction
  • Pupillometry

ASJC Scopus subject areas

  • Biomedical Engineering


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