PURPOSE OF REVIEW: Cancer is one of the leading causes of death and the incidence rates are constantly rising. The heterogeneity of tumors poses a big challenge for the treatment of the disease and natural antibodies additionally affect disease progression. The introduction of engineered mAbs for anticancer immunotherapies has substantially improved progression-free and overall survival of cancer patients, but little efforts have been made to exploit other antibody isotypes than IgG.
RECENT FINDINGS: In order to improve these therapies, 'next-generation antibodies' were engineered to enhance a specific feature of classical antibodies and form a group of highly effective and precise therapy compounds. Advanced antibody approaches include among others antibody-drug conjugates, glyco-engineered and Fc-engineered antibodies, antibody fragments, radioimmunotherapy compounds, bispecific antibodies and alternative (non-IgG) immunoglobulin classes, especially IgE.
SUMMARY: The current review describes solutions for the needs of next-generation antibody therapies through different approaches. Careful selection of the best-suited engineering methodology is a key factor in developing personalized, more specific and more efficient mAbs against cancer to improve the outcomes of cancer patients. We highlight here the large evidence of IgE exploiting a highly cytotoxic effector arm as potential next-generation anticancer immunotherapy.
|Number of pages
|Current Opinion in Allergy and Clinical Immunology
|Published - 01 Jun 2020
- Antibodies, Bispecific/therapeutic use
- Antibodies, Monoclonal/therapeutic use
- Antineoplastic Agents, Immunological/therapeutic use
- Drug Resistance, Neoplasm/genetics
- Immunoconjugates/therapeutic use
- Immunoglobulin E/therapeutic use
- Immunoglobulin Fc Fragments/therapeutic use
- Medical Oncology/methods
- Neoplasms/drug therapy
- Precision Medicine/methods
- Progression-Free Survival
- Protein Engineering
- Tumor Escape/genetics
- tumor-associated antigens
- immunotherapy of cancer
- antibody optimization approaches
ASJC Scopus subject areas
- Immunology and Allergy