Papillomavirus-like Particles in Equine Medicine

Edmund K Hainisch, Christoph Jindra, Reinhard Kirnbauer, Sabine Brandt

Research output: Journal article (peer-reviewed)Review article

2 Citations (Scopus)

Abstract

Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.

Original languageEnglish
Article number345
JournalViruses
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2023

Keywords

  • Humans
  • Animals
  • Horses
  • Papillomaviridae/genetics
  • Capsid
  • Capsid Proteins/genetics

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