Papillomavirus-like Particles in Equine Medicine

Edmund K Hainisch; Christoph Jindra; Reinhard Kirnbauer; Sabine Brandt

doi:10.3390/v15020345

Papillomavirus-like Particles in Equine Medicine

Edmund K Hainisch, Christoph Jindra, Reinhard Kirnbauer, Sabine Brandt

Karl Landsteiner University of Health Sciences

Research output: Journal article (peer-reviewed) › Review article

3 Citations (Scopus)

Abstract

Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.

Original language	English
Article number	345
Journal	Viruses
Volume	15
Issue number	2
DOIs	https://doi.org/10.3390/v15020345
Publication status	Published - Feb 2023

Keywords

Humans
Animals
Horses
Papillomaviridae/genetics
Capsid
Capsid Proteins/genetics

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10.3390/v15020345

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@article{41a476233b3647799313f011630815a4,

title = "Papillomavirus-like Particles in Equine Medicine",

abstract = "Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.",

keywords = "Humans, Animals, Horses, Papillomaviridae/genetics, Capsid, Capsid Proteins/genetics",

author = "Hainisch, {Edmund K} and Christoph Jindra and Reinhard Kirnbauer and Sabine Brandt",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = feb,

doi = "10.3390/v15020345",

language = "English",

volume = "15",

journal = "Viruses",

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TY - JOUR

T1 - Papillomavirus-like Particles in Equine Medicine

AU - Hainisch, Edmund K

AU - Jindra, Christoph

AU - Kirnbauer, Reinhard

AU - Brandt, Sabine

PY - 2023/2

Y1 - 2023/2

N2 - Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.

AB - Papillomaviruses (PVs) are a family of small DNA tumor viruses that can induce benign lesions or cancer in vertebrates. The observation that animal PV capsid-proteins spontaneously self-assemble to empty, highly immunogenic virus-like particles (VLPs) has led to the establishment of vaccines that efficiently protect humans from specific PV infections and associated diseases. We provide an overview of PV-induced tumors in horses and other equids, discuss possible routes of PV transmission in equid species, and present recent developments aiming at introducing the PV VLP-based vaccine technology into equine medicine.

KW - Humans

KW - Animals

KW - Horses

KW - Papillomaviridae/genetics

KW - Capsid

KW - Capsid Proteins/genetics

UR - http://www.scopus.com/inward/record.url?scp=85148973308&partnerID=8YFLogxK

U2 - 10.3390/v15020345

DO - 10.3390/v15020345

M3 - Review article

C2 - 36851559

SN - 1999-4915

VL - 15

JO - Viruses

JF - Viruses

IS - 2

M1 - 345

ER -

Papillomavirus-like Particles in Equine Medicine

Abstract

Keywords

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