TY - JOUR
T1 - Nrf2-interacting nutrients and COVID-19
T2 - time for research to develop adaptation strategies
AU - the ARIA group
AU - Bousquet, Jean
AU - Cristol, Jean Paul
AU - Czarlewski, Wienczyslawa
AU - Anto, Josep M.
AU - Martineau, Adrian
AU - Haahtela, Tari
AU - Fonseca, Susana C.
AU - Iaccarino, Guido
AU - Blain, Hubert
AU - Fiocchi, Alessandro
AU - Canonica, G. Walter
AU - Fonseca, Joao A.
AU - Vidal, Alain
AU - Choi, Hak Jong
AU - Kim, Hyun Ju
AU - Le Moing, Vincent
AU - Reynes, Jacques
AU - Sheikh, Aziz
AU - Akdis, Cezmi A.
AU - Zuberbier, Torsten
AU - Abdul Latiff, Amir Hamzah
AU - Abdullah, Baharudin
AU - Aberer, Werner
AU - Abusada, Nancy
AU - Adcock, Ian
AU - Afani, Alejandro
AU - Agache, Ioana
AU - Aggelidis, Xenofon
AU - Agustin, Jenifer
AU - Akdis, Mübeccel
AU - Al-Ahmad, Mona
AU - Al-Zahab Bassam, Abou
AU - Alburdan, Hussam
AU - Aldrey-Palacios, Oscar
AU - Alvarez Cuesta, Emilio
AU - Alwan Salman, Hiba
AU - Alzaabi, Ashraf
AU - Amade, Salma
AU - Ambrocio, Gene
AU - Angles, Rosana
AU - Annesi-Maesano, Isabella
AU - Ansotegui, Ignacio J.
AU - Ara Bardajo, Paula
AU - Arasi, Stefania
AU - Arrais, Margarete
AU - Arshad, Hasan
AU - Artesani, Maria Cristina
AU - Asayag, Estrella
AU - Eiwegger, Thomas
AU - Valenta, Rudolf
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/3
Y1 - 2020/12/3
N2 - There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
AB - There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
KW - COVID-19
KW - Foods
KW - Insulin resistance
KW - Nrf2
KW - Nutrients
KW - Obesity
KW - TRPA1
UR - http://www.scopus.com/inward/record.url?scp=85098217862&partnerID=8YFLogxK
U2 - 10.1186/s13601-020-00362-7
DO - 10.1186/s13601-020-00362-7
M3 - Review article
C2 - 33292691
AN - SCOPUS:85098217862
SN - 2045-7022
VL - 10
JO - Clinical and Translational Allergy
JF - Clinical and Translational Allergy
IS - 1
M1 - 58
ER -