TY - JOUR
T1 - Non-celiac gluten sensitivity
T2 - The new frontier of gluten related disorders
AU - Catassi, Carlo
AU - Bai, Julio C.
AU - Bonaz, Bruno
AU - Bouma, Gerd
AU - Calabrò, Antonio
AU - Carroccio, Antonio
AU - Castillejo, Gemma
AU - Ciacci, Carolina
AU - Cristofori, Fernanda
AU - Dolinsek, Jernej
AU - Francavilla, Ruggiero
AU - Elli, Luca
AU - Green, Peter
AU - Holtmeier, Wolfgang
AU - Koehler, Peter
AU - Koletzko, Sibylle
AU - Meinhold, Christof
AU - Sanders, David
AU - Schumann, Michael
AU - Schuppan, Detlef
AU - Ullrich, Reiner
AU - Vécsei, Andreas
AU - Volta, Umberto
AU - Zevallos, Victor
AU - Sapone, Anna
AU - Fasano, Alessio
PY - 2013
Y1 - 2013
N2 - Non Celiac Gluten sensitivity (NCGS) was originally described in the 1980s and recently a "re-discovered" disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA). Although NCGS frequency is still unclear, epidemiological data have been generated that can help establishing the magnitude of the problem. Clinical studies further defined the identity of NCGS and its implications in human disease. An overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria. Several studies suggested a relationship between NCGS and neuropsychiatric disorders, particularly autism and schizophrenia. The first case reports of NCGS in children have been described. Lack of biomarkers is still a major limitation of clinical studies, making it difficult to differentiate NCGS from other gluten related disorders. Recent studies raised the possibility that, beside gluten, wheat amylase-trypsin inhibitors and low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we report the major advances and current trends on NCGS.
AB - Non Celiac Gluten sensitivity (NCGS) was originally described in the 1980s and recently a "re-discovered" disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA). Although NCGS frequency is still unclear, epidemiological data have been generated that can help establishing the magnitude of the problem. Clinical studies further defined the identity of NCGS and its implications in human disease. An overlap between the irritable bowel syndrome (IBS) and NCGS has been detected, requiring even more stringent diagnostic criteria. Several studies suggested a relationship between NCGS and neuropsychiatric disorders, particularly autism and schizophrenia. The first case reports of NCGS in children have been described. Lack of biomarkers is still a major limitation of clinical studies, making it difficult to differentiate NCGS from other gluten related disorders. Recent studies raised the possibility that, beside gluten, wheat amylase-trypsin inhibitors and low-fermentable, poorly-absorbed, short-chain carbohydrates can contribute to symptoms (at least those related to IBS) experienced by NCGS patients. In this paper we report the major advances and current trends on NCGS.
KW - Celiac disease
KW - Gluten sensitivity
KW - Gluten-free diet
KW - Gluten-related disorders
KW - Wheat allergy
UR - http://www.scopus.com/inward/record.url?scp=84884678558&partnerID=8YFLogxK
U2 - 10.3390/nu5103839
DO - 10.3390/nu5103839
M3 - Review article
C2 - 24077239
AN - SCOPUS:84884678558
SN - 2072-6643
VL - 5
SP - 3839
EP - 3853
JO - Nutrients
JF - Nutrients
IS - 10
ER -