Multiple calcified brain metastases in a man with invasive ductal breast cancer

Nadine Ressl, Stefan Oberndorfer

Research output: Journal article (peer-reviewed)Case report

3 Citations (Scopus)


We report a case of a 52-year-old Caucasian man with invasive ductal carcinoma of the breast. One year after initial diagnosis, he developed a generalised epileptic seizure and neuroimaging showed multiple, calcified intracerebral lesions. Owing to these atypical cerebral imaging findings, comprehensive serological and cerebrospinal fluid analysis was conducted and a latent toxoplasmosis was suspected. In order to distinguish between metastases and an infectious disease, a cerebral biopsy was performed, which verified brain metastases. The patient received whole-brain radiotherapy. The last cerebral CT scan, 18 months later showed stable disease. Calcification of brain metastases in patients with breast cancer is very rare. Owing to their non-characteristic radiological appearance with a lack of contrast enhancement, diagnosis of metastases can be difficult. Infectious diseases should be considered within the diagnostic work up. Owing to possible pitfalls, we recommend a widespread differential diagnostic work up in similar cases, and even in cases with a confirmed primary tumour.

Original languageEnglish
Article numberA1608
JournalBMJ Case Reports
Publication statusPublished - 15 Oct 2015


  • Brain Neoplasms/pathology
  • Breast Neoplasms, Male/pathology
  • Calcinosis/pathology
  • Carcinoma, Ductal, Breast/pathology
  • Humans
  • Male
  • Middle Aged

ASJC Scopus subject areas

  • General Medicine


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