Abstract
Biliary tract cancers (BTCs), including intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), and gallbladder carcinoma (GBC), are rare but biologically aggressive malignancies with historically limited treatment options and dismal prognosis. The median overall survival in advanced stages remains below 13 months despite chemotherapy and recent immunotherapy advances. However, molecular profiling has revealed targetable genetic alterations in up to 40% of BTCs, enabling the development and application of targeted therapies. This review provides an overview of the molecular landscape of BTC, describes the clinical relevance of key genomic alterations, discusses approved targeted agents, and highlights current implementation challenges and future directions in precision oncology.
| Original language | English |
|---|---|
| Pages (from-to) | 279-282 |
| Number of pages | 4 |
| Journal | Memo - Magazine of European Medical Oncology |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2025 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Biliary tract cancer
- Precision oncology
- IDH2
- Cholangiocarcinoma
- FGFR2
ASJC Scopus subject areas
- Hematology
- Oncology
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