MM-associated anemia: more than "crowding out" HSPCs

Research output: Journal article (peer-reviewed)Journal article

1 Citation (Scopus)


In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.

Original languageEnglish
Pages (from-to)2539-2540
Number of pages2
Issue number13
Publication statusPublished - 27 Sept 2012
Externally publishedYes


  • Animals
  • Antigens, CD34/metabolism
  • Biomarkers/metabolism
  • Bone Marrow/pathology
  • Female
  • Hematopoietic Stem Cells/pathology
  • Humans
  • Male
  • Megakaryocyte-Erythroid Progenitor Cells/pathology
  • Multiple Myeloma/metabolism


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