MM-associated anemia: more than "crowding out" HSPCs

Klaus Podar

doi:10.1182/blood-2012-05-425983

MM-associated anemia: more than "crowding out" HSPCs

Klaus Podar

Research output: Journal article (peer-reviewed) › Journal article

1 Citation (Scopus)

Abstract

In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.

Original language	English
Pages (from-to)	2539-2540
Number of pages	2
Journal	Blood
Volume	120
Issue number	13
DOIs	https://doi.org/10.1182/blood-2012-05-425983
Publication status	Published - 27 Sept 2012
Externally published	Yes

Keywords

Animals
Antigens, CD34/metabolism
Biomarkers/metabolism
Bone Marrow/pathology
Female
Hematopoietic Stem Cells/pathology
Humans
Male
Megakaryocyte-Erythroid Progenitor Cells/pathology
Multiple Myeloma/metabolism

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10.1182/blood-2012-05-425983

Cite this

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title = "MM-associated anemia: more than {"}crowding out{"} HSPCs",

abstract = "In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.",

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doi = "10.1182/blood-2012-05-425983",

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AB - In this issue of Blood, Bruns et al report that hematopoietic stem and progenitor cells are significantly decreased in the bone marrow of multiple myeloma (MM) patients. Based on their insightful findings the authors claim that hematopoietic suppression depends on cues (eg, the activation of TGFβ signaling pathways) within the MM milieu and is reversible in a MM-free bone marrow microenvironment.

KW - Animals

KW - Antigens, CD34/metabolism

KW - Biomarkers/metabolism

KW - Bone Marrow/pathology

KW - Female

KW - Hematopoietic Stem Cells/pathology

KW - Humans

KW - Male

KW - Megakaryocyte-Erythroid Progenitor Cells/pathology

KW - Multiple Myeloma/metabolism

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U2 - 10.1182/blood-2012-05-425983

DO - 10.1182/blood-2012-05-425983

M3 - Journal article

C2 - 23019201

SN - 0006-4971

VL - 120

SP - 2539

EP - 2540

JO - Blood

JF - Blood

IS - 13

ER -

MM-associated anemia: more than "crowding out" HSPCs

Abstract

Keywords

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