TY - JOUR
T1 - Management of malignant pleural mesothelioma - part 3
T2 - Data from the Austrian Mesothelioma Interest Group (AMIG) database
AU - Klikovits, Thomas
AU - Hoda, Mir Alireza
AU - Dong, Yawen
AU - Arns, Madeleine
AU - Baumgartner, Bernhard
AU - Errhalt, Peter
AU - Geltner, Christian
AU - Machan, Barbara
AU - Pohl, Wolfgang
AU - Hutter, Jörg
AU - Eckmayr, Josef
AU - Studnicka, Michael
AU - Flicker, Martin
AU - Cerkl, Peter
AU - Kirchbacher, Klaus
AU - Klepetko, Walter
N1 - Publisher Copyright:
© 2016, The Author(s).
PY - 2016/9/1
Y1 - 2016/9/1
N2 - BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor originating from the pleural cavity with a strong link to previous asbestos exposure. In order to determine the demographics, diagnostics, therapeutic strategies, and prognosis of MPM patients in Austria, the Austrian Mesothelioma Interest Group (AMIG) was founded in 2011. In this report the data from the AMIG MPM database collected to date are reported.METHODS: A prospective observational registry was initiated, including patients with histologically verified MPM diagnosed and treated at specialized centers in Austria. Patient inclusion started in January 2011 and follow-up was completed until September 2015.RESULTS: A total number of 210 patients were included. There were 167 male and 43 female patients with a mean age of 67.0 years (SD ± 11.3) at the time of diagnosis. Asbestos exposure was confirmed in 109 (69.4 %) patients. The histological subtype was epithelioid in 141 (67.2 %), sarcomatoid in 16 (7.6 %), biphasic in 28 (13.3 %), and MPM not otherwise specified in 25 (11.9 %) patients. Of the patients, 30 (14.3 %) received best supportive care (BSC) only, 71 (33.8 %) chemotherapy (CHT) alone, four (1.9 %) radiotherapy (RT) alone, 23 (11.9 %) CHT/RT, two (0.9 %) surgery alone, and 76 (36.2 %) curative surgery within a multimodality treatment (MMT), which was more frequently performed for patients younger than 65 years and with early-stage disease (I + II). Median overall survival (OS) was 19.1 months (95 % CI 14.7-23.5). The 1‑, 3‑, and 5‑year OS rates were 66 %, 30 %, and 23 %, respectively, and OS was significantly better in patients undergoing surgery within MMT (5-year survival 5 % vs. 40 %, p = 0.001).CONCLUSION: Patients with earlier disease stages, younger age, good performance status, and epithelioid histology were more likely to undergo MMT including surgery, which resulted in a more favorable outcome.
AB - BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare but aggressive tumor originating from the pleural cavity with a strong link to previous asbestos exposure. In order to determine the demographics, diagnostics, therapeutic strategies, and prognosis of MPM patients in Austria, the Austrian Mesothelioma Interest Group (AMIG) was founded in 2011. In this report the data from the AMIG MPM database collected to date are reported.METHODS: A prospective observational registry was initiated, including patients with histologically verified MPM diagnosed and treated at specialized centers in Austria. Patient inclusion started in January 2011 and follow-up was completed until September 2015.RESULTS: A total number of 210 patients were included. There were 167 male and 43 female patients with a mean age of 67.0 years (SD ± 11.3) at the time of diagnosis. Asbestos exposure was confirmed in 109 (69.4 %) patients. The histological subtype was epithelioid in 141 (67.2 %), sarcomatoid in 16 (7.6 %), biphasic in 28 (13.3 %), and MPM not otherwise specified in 25 (11.9 %) patients. Of the patients, 30 (14.3 %) received best supportive care (BSC) only, 71 (33.8 %) chemotherapy (CHT) alone, four (1.9 %) radiotherapy (RT) alone, 23 (11.9 %) CHT/RT, two (0.9 %) surgery alone, and 76 (36.2 %) curative surgery within a multimodality treatment (MMT), which was more frequently performed for patients younger than 65 years and with early-stage disease (I + II). Median overall survival (OS) was 19.1 months (95 % CI 14.7-23.5). The 1‑, 3‑, and 5‑year OS rates were 66 %, 30 %, and 23 %, respectively, and OS was significantly better in patients undergoing surgery within MMT (5-year survival 5 % vs. 40 %, p = 0.001).CONCLUSION: Patients with earlier disease stages, younger age, good performance status, and epithelioid histology were more likely to undergo MMT including surgery, which resulted in a more favorable outcome.
KW - Adult
KW - Age Distribution
KW - Aged
KW - Aged, 80 and over
KW - Asbestosis/mortality
KW - Austria/epidemiology
KW - Female
KW - Humans
KW - Male
KW - Mesothelioma/diagnosis
KW - Middle Aged
KW - Pleural Effusion, Malignant/mortality
KW - Pleural Neoplasms/mortality
KW - Prevalence
KW - Registries
KW - Risk Factors
KW - Sex Distribution
KW - Survival Rate
UR - http://www.scopus.com/inward/record.url?scp=84979503065&partnerID=8YFLogxK
U2 - 10.1007/s00508-016-1037-2
DO - 10.1007/s00508-016-1037-2
M3 - Journal article
C2 - 27457873
SN - 0043-5325
VL - 128
SP - 627
EP - 634
JO - Wiener Klinische Wochenschrift
JF - Wiener Klinische Wochenschrift
IS - 17-18
ER -