Magnetic resonance imaging biomarkers for clinical routine assessment of microvascular architecture in glioma

Andreas Stadlbauer, Max Zimmermann, Gertraud Heinz, Stefan Oberndorfer, Arnd Doerfler, Michael Buchfelder, Karl Rössler

Research output: Journal article (peer-reviewed)Journal article

29 Citations (Scopus)

Abstract

Knowledge about the topological and structural heterogeneity of the microvasculature is important for diagnosis and monitoring of glioma. A vessel caliber and type-dependent temporal shift in the magnetic resonance imaging signal forms the basis for vascular architecture mapping. This study introduced a clinically feasible approach for assessment of vascular pathologies in gliomas using vascular architecture mapping. Sixty consecutive patients with known or suspected gliomas were examined using vascular architecture mapping as part of the routine magnetic resonance imaging protocol. Maps of microvessel radius and density, which adapted to the vasculature-dependent temporal shift phenomenon, were calculated using a costume-made software tool. Microvessel radius and density were moderately to severely elevated in a heterogeneous, inversely correlated pattern within high-grade gliomas. Additionally, three new imaging biomarkers were introduced: Microvessel type indicator allowing differentiation between supplying arterial and draining venous microvasculature in high-grade gliomas. Vascular-induced bolus peak time shift may presumably be sensitive for early neovascularization in the infiltration zone. Surprisingly, curvature showed significant changes in peritumoral vasogenic edema which correlated with neovascularization in the tumor core of high-grade gliomas. These new magnetic resonance imaging biomarkers give insights into complexity and heterogeneity of vascular changes in glioma; however, histological validations in more well-defined patient populations are required.

Original languageEnglish
Pages (from-to)632-643
Number of pages12
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number2
DOIs
Publication statusPublished - Feb 2017

Keywords

  • Adult
  • Aged
  • Brain/blood supply
  • Brain Neoplasms/blood supply
  • Female
  • Glioma/blood supply
  • Humans
  • Magnetic Resonance Imaging/methods
  • Male
  • Microvessels/diagnostic imaging
  • Middle Aged

Fingerprint

Dive into the research topics of 'Magnetic resonance imaging biomarkers for clinical routine assessment of microvascular architecture in glioma'. Together they form a unique fingerprint.

Cite this