Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

Mübeccel Akdis; Simone Burgler; Reto Crameri; Thomas Eiwegger; Hiroyuki Fujita; Enrique Gomez; Sven Klunker; Norbert Meyer; Liam O'Mahony; Oscar Palomares; Claudio Rhyner; Nadia Quaked; Anna Schaffartzik; Willem Van De Veen; Sabine Zeller; Maya Zimmermann; Cezmi A. Akdis

doi:10.1016/j.jaci.2010.11.050

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

Mübeccel Akdis, Simone Burgler, Reto Crameri, Thomas Eiwegger, Hiroyuki Fujita, Enrique Gomez, Sven Klunker, Norbert Meyer, Liam O'Mahony, Oscar Palomares, Claudio Rhyner, Nadia Quaked, Anna Schaffartzik, Willem Van De Veen, Sabine Zeller, Maya Zimmermann, Cezmi A. Akdis

Research output: Journal article (peer-reviewed) › Journal article

663 Citations (Scopus)

Abstract

Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among T_h and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-γ. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections.

Original language	English
Pages (from-to)	701-721.e70
Journal	Journal of Allergy and Clinical Immunology
Volume	127
Issue number	3
DOIs	https://doi.org/10.1016/j.jaci.2010.11.050
Publication status	Published - Mar 2011
Externally published	Yes

Keywords

adaptive immune response
allergy and asthma
B cells
Cytokines
dendritic cells
humoral immune response
interleukins
T cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.jaci.2010.11.050

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Akdis, M., Burgler, S., Crameri, R., Eiwegger, T., Fujita, H., Gomez, E., Klunker, S., Meyer, N., O'Mahony, L., Palomares, O., Rhyner, C., Quaked, N., Schaffartzik, A., Van De Veen, W., Zeller, S., Zimmermann, M., & Akdis, C. A. (2011). Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases. Journal of Allergy and Clinical Immunology, 127(3), 701-721.e70. https://doi.org/10.1016/j.jaci.2010.11.050

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abstract = "Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among Th and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-γ. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections.",

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author = "M{\"u}beccel Akdis and Simone Burgler and Reto Crameri and Thomas Eiwegger and Hiroyuki Fujita and Enrique Gomez and Sven Klunker and Norbert Meyer and Liam O'Mahony and Oscar Palomares and Claudio Rhyner and Nadia Quaked and Anna Schaffartzik and {Van De Veen}, Willem and Sabine Zeller and Maya Zimmermann and Akdis, {Cezmi A.}",

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Akdis, M, Burgler, S, Crameri, R, Eiwegger, T, Fujita, H, Gomez, E, Klunker, S, Meyer, N, O'Mahony, L, Palomares, O, Rhyner, C, Quaked, N, Schaffartzik, A, Van De Veen, W, Zeller, S, Zimmermann, M & Akdis, CA 2011, 'Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases', Journal of Allergy and Clinical Immunology, vol. 127, no. 3, pp. 701-721.e70. https://doi.org/10.1016/j.jaci.2010.11.050

TY - JOUR

T1 - Interleukins, from 1 to 37, and interferon-γ

T2 - Receptors, functions, and roles in diseases

AU - Akdis, Mübeccel

AU - Burgler, Simone

AU - Crameri, Reto

AU - Eiwegger, Thomas

AU - Fujita, Hiroyuki

AU - Gomez, Enrique

AU - Klunker, Sven

AU - Meyer, Norbert

AU - O'Mahony, Liam

AU - Palomares, Oscar

AU - Rhyner, Claudio

AU - Quaked, Nadia

AU - Schaffartzik, Anna

AU - Van De Veen, Willem

AU - Zeller, Sabine

AU - Zimmermann, Maya

AU - Akdis, Cezmi A.

PY - 2011/3

Y1 - 2011/3

N2 - Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among Th and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-γ. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections.

AB - Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among Th and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-γ. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections.

KW - adaptive immune response

KW - allergy and asthma

KW - B cells

KW - Cytokines

KW - dendritic cells

KW - humoral immune response

KW - interleukins

KW - T cells

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DO - 10.1016/j.jaci.2010.11.050

M3 - Journal article

AN - SCOPUS:79952291528

SN - 0091-6749

VL - 127

SP - 701-721.e70

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

Abstract

Keywords

ASJC Scopus subject areas

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