Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

Mübeccel Akdis, Simone Burgler, Reto Crameri, Thomas Eiwegger, Hiroyuki Fujita, Enrique Gomez, Sven Klunker, Norbert Meyer, Liam O'Mahony, Oscar Palomares, Claudio Rhyner, Nadia Quaked, Anna Schaffartzik, Willem Van De Veen, Sabine Zeller, Maya Zimmermann, Cezmi A. Akdis

Research output: Journal article (peer-reviewed)Journal article

643 Citations (Scopus)

Abstract

Advancing our understanding of mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections could lead to effective and targeted therapies. Subsets of immune and inflammatory cells interact via ILs and IFNs; reciprocal regulation and counter balance among Th and regulatory T cells, as well as subsets of B cells, offer opportunities for immune interventions. Here, we review current knowledge about ILs 1 to 37 and IFN-γ. Our understanding of the effects of ILs has greatly increased since the discoveries of monocyte IL (called IL-1) and lymphocyte IL (called IL-2); more than 40 cytokines are now designated as ILs. Studies of transgenic or knockout mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided important information about IL and IFN functions. We discuss their signaling pathways, cellular sources, targets, roles in immune regulation and cellular networks, roles in allergy and asthma, and roles in defense against infections.

Original languageEnglish
Pages (from-to)701-721.e70
JournalJournal of Allergy and Clinical Immunology
Volume127
Issue number3
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Keywords

  • adaptive immune response
  • allergy and asthma
  • B cells
  • Cytokines
  • dendritic cells
  • humoral immune response
  • interleukins
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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