Abstract
People worldwide are living longer, and the incidence
of hip fracture risk increases exponentially with age.
Loss of bone mass and falls are the primary causes of
hip fractures, but bone mechanical integrity at the
microscale was also reported to increase with
mineralisation and decline with age. Macroscopic tests
of the proximal part of the femur are prone to errors,
and corresponding μFE models become exceedingly
large. In contrast, compressive testing of bone sections
was shown to be accurate. Therefore, we performed
compressive tests of femoral neck sections and
simulated the same tests with non-linear μFE [1]. We
hypothesised that the micromechanical parameters of
the μFE models must decrease with age in order to
match the macroscopic experimental response.
of hip fracture risk increases exponentially with age.
Loss of bone mass and falls are the primary causes of
hip fractures, but bone mechanical integrity at the
microscale was also reported to increase with
mineralisation and decline with age. Macroscopic tests
of the proximal part of the femur are prone to errors,
and corresponding μFE models become exceedingly
large. In contrast, compressive testing of bone sections
was shown to be accurate. Therefore, we performed
compressive tests of femoral neck sections and
simulated the same tests with non-linear μFE [1]. We
hypothesised that the micromechanical parameters of
the μFE models must decrease with age in order to
match the macroscopic experimental response.
| Original language | English |
|---|---|
| Publication status | Published - 2022 |