Impact of maternally derived meiotic aneuploidies on early embryonic development in vitro

Lena Tschare, A Ennemoser, L Carli, E Vaccari, M Feichtinger

Research output: Journal article (peer-reviewed)Journal article


Purpose: To assess early embryonic developmental potential of embryos affected by maternally inherited meiotic aneuploidies. Methods: This observational, descriptive study includes 930 oocytes from 151 patients which were retrospectively analyzed by combining the morphological assessment with the genetic results from polar body diagnosis. Results: Of 930 oocytes examined, 566 (60.9%) were tested aneuploid. Developmental potential until cleavage stage was not affected by trisomies or monosomies (69.6% vs. 77.1%, p = 0.75). However, trisomies significantly more often resulted in top quality cleavage stage embryos compared to monosomies (20% vs. 17.6%, p = < 0.01). Top quality blastocysts were more likely to be euploid than aneuploid (52.4% vs. 47.6%, p = 0.032). Additionally, significantly more aneuploid embryos resulted in developmental arrest compared to euploid embryos (15.3% vs. 6.7%, p = 0.003). Overall, there was no significant difference in the frequency of trisomies and monosomies in blastocyst stage embryos. (28.3% vs. 28.2%; p = 0.81). In contrast to earlier developmental stages, distribution of trisomies and monosomies did not differ in top quality blastocysts (8.3% vs. 5.3%, p = 0.32). However, certain chromosomal abnormalities showed a higher potential to develop into a top-rated blastocyst. These included monosomies 2, 5, 8, 10, 16, 17, 20, 21, and 22 and trisomies 2, 4, 5, 8, 9, 10, 11, 12, 13, 16, 17, 18 and 20. Conclusion: Meiotically induced maternal aneuploidies have different effects on early embryonic development. While no difference in developmental potential between monosomies and trisomies could be observed in blastocysts, cleavage stage quality was significantly affected by chromosomal aneuploidies.

Original languageEnglish
Pages (from-to)2715-2723
Number of pages9
JournalJournal of Assisted Reproduction and Genetics
Issue number11
Early online date26 Aug 2023
Publication statusPublished - Nov 2023


  • Aneuploidies
  • IVF
  • Polar bodies
  • PGT-A
  • Embryo quality
  • Trisomy
  • Humans
  • Blastocyst
  • Aneuploidy
  • Pregnancy
  • Embryonic Development/genetics
  • Preimplantation Diagnosis/methods
  • Female
  • Retrospective Studies
  • Monosomy

ASJC Scopus subject areas

  • Genetics (clinical)
  • Genetics
  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology


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