Hämodynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen Änderung durch das 6 th World Symposium on Pulmonary Hypertension

Stephan Rosenkranz; Gerhard Paul Diller; Daniel Dumitrescu; Ralf Ewert; H. Ardeschir Ghofrani; Ekkehard Grünig; Michael Halank; Matthias Held; Harald Kaemmerer; Hans Klose; Gabor Kovacs; Stavros Konstantinides; Irene M. Lang; Tobias J. Lange; Hanno Leuchte; Eckhard Mayer; Andrea Olschewski; Horst Olschewski; Karen M. Olsson; Christian Opitz; Ralph T. Schermuly; Werner Seeger; Heinrike Wilkens; Marius M. Hoeper

doi:10.1055/a-0918-3772

Hämodynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen Änderung durch das 6 ^th World Symposium on Pulmonary Hypertension

Translated title of the contribution: Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6 ^th World Symposium on Pulmonary Hypertension

Stephan Rosenkranz^*
, Gerhard Paul Diller
, Daniel Dumitrescu
, Ralf Ewert
, H. Ardeschir Ghofrani
, Ekkehard Grünig
, Michael Halank
, Matthias Held
, Harald Kaemmerer
, Hans Klose
, Gabor Kovacs
, Stavros Konstantinides
, Irene M. Lang
, Tobias J. Lange
, Hanno Leuchte
, Eckhard Mayer
, Andrea Olschewski
, Horst Olschewski
, Karen M. Olsson
, Christian Opitz

Ralph T. Schermuly, Werner Seeger, Heinrike Wilkens, Marius M. Hoeper

^*Corresponding author for this work

Research output: Journal article (peer-reviewed) › Journal article

13 Citations (Scopus)

Abstract

The ESC/ERS guidelines (published at the end of 2015) and other international recommendations defined pulmonary hypertension (PH) by an invasively measured mean pulmonary arterial pressure (mPAP) ≥25mmHg at rest. At the 6 ^th World Symposium on Pulmonary Hypertension in Nice a modification of this hemodynamic definition in the sense of lowering the threshold to >20mmHg was proposed. A pulmonary vascular resistance (PVR) ≥3 Wood units (WU) is additionally required for the diagnosis of pre-capillary PH. This modification must be critically reviewed with regard to the underlying rationale and possible consequences. Therefore, a detailed explanation is required. In particular, it must be made clear that this change currently has no influence on the evidence-based and approval-compliant prescription of drugs for the targeted therapy of pulmonary arterial hypertension (PAH).

Translated title of the contribution	Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6 ^th World Symposium on Pulmonary Hypertension
Original language	German
Pages (from-to)	1367-1372
Number of pages	6
Journal	Deutsche Medizinische Wochenschrift
Volume	144
Issue number	19
DOIs	https://doi.org/10.1055/a-0918-3772
Publication status	Published - 26 Sept 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Medicine

Access to Document

10.1055/a-0918-3772

Cite this

Rosenkranz, S., Diller, G. P., Dumitrescu, D., Ewert, R., Ghofrani, H. A., Grünig, E., Halank, M., Held, M., Kaemmerer, H., Klose, H., Kovacs, G., Konstantinides, S., Lang, I. M., Lange, T. J., Leuchte, H., Mayer, E., Olschewski, A., Olschewski, H., Olsson, K. M., ... Hoeper, M. M. (2019). Hämodynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen Änderung durch das 6 ^th World Symposium on Pulmonary Hypertension. Deutsche Medizinische Wochenschrift, 144(19), 1367-1372. https://doi.org/10.1055/a-0918-3772

@article{f465de7ddf1d4a7985264a6e233a5e25,

title = "H{\"a}modynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen {\"A}nderung durch das 6 th World Symposium on Pulmonary Hypertension",

abstract = "The ESC/ERS guidelines (published at the end of 2015) and other international recommendations defined pulmonary hypertension (PH) by an invasively measured mean pulmonary arterial pressure (mPAP) ≥25mmHg at rest. At the 6 th World Symposium on Pulmonary Hypertension in Nice a modification of this hemodynamic definition in the sense of lowering the threshold to >20mmHg was proposed. A pulmonary vascular resistance (PVR) ≥3 Wood units (WU) is additionally required for the diagnosis of pre-capillary PH. This modification must be critically reviewed with regard to the underlying rationale and possible consequences. Therefore, a detailed explanation is required. In particular, it must be made clear that this change currently has no influence on the evidence-based and approval-compliant prescription of drugs for the targeted therapy of pulmonary arterial hypertension (PAH).",

keywords = "hemodynamic definition, prognosis, pulmonary hypertension",

author = "Stephan Rosenkranz and Diller, \{Gerhard Paul\} and Daniel Dumitrescu and Ralf Ewert and Ghofrani, \{H. Ardeschir\} and Ekkehard Gr{\"u}nig and Michael Halank and Matthias Held and Harald Kaemmerer and Hans Klose and Gabor Kovacs and Stavros Konstantinides and Lang, \{Irene M.\} and Lange, \{Tobias J.\} and Hanno Leuchte and Eckhard Mayer and Andrea Olschewski and Horst Olschewski and Olsson, \{Karen M.\} and Christian Opitz and Schermuly, \{Ralph T.\} and Werner Seeger and Heinrike Wilkens and Hoeper, \{Marius M.\}",

year = "2019",

month = sep,

day = "26",

doi = "10.1055/a-0918-3772",

language = "Deutsch",

volume = "144",

pages = "1367--1372",

journal = "Deutsche Medizinische Wochenschrift",

issn = "0012-0472",

publisher = "Georg Thieme Verlag",

number = "19",

}

Rosenkranz, S, Diller, GP, Dumitrescu, D, Ewert, R, Ghofrani, HA, Grünig, E, Halank, M, Held, M, Kaemmerer, H, Klose, H, Kovacs, G, Konstantinides, S, Lang, IM, Lange, TJ, Leuchte, H, Mayer, E, Olschewski, A, Olschewski, H, Olsson, KM, Opitz, C, Schermuly, RT, Seeger, W, Wilkens, H & Hoeper, MM 2019, 'Hämodynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen Änderung durch das 6 ^th World Symposium on Pulmonary Hypertension', Deutsche Medizinische Wochenschrift, vol. 144, no. 19, pp. 1367-1372. https://doi.org/10.1055/a-0918-3772

Hämodynamische Definition der pulmonalen Hypertonie: Kommentar zu der vorgeschlagenen Änderung durch das 6 ^th World Symposium on Pulmonary Hypertension. / Rosenkranz, Stephan; Diller, Gerhard Paul; Dumitrescu, Daniel et al.
In: Deutsche Medizinische Wochenschrift, Vol. 144, No. 19, 26.09.2019, p. 1367-1372.

Research output: Journal article (peer-reviewed) › Journal article

TY - JOUR

T1 - Hämodynamische Definition der pulmonalen Hypertonie

T2 - Kommentar zu der vorgeschlagenen Änderung durch das 6 th World Symposium on Pulmonary Hypertension

AU - Rosenkranz, Stephan

AU - Diller, Gerhard Paul

AU - Dumitrescu, Daniel

AU - Ewert, Ralf

AU - Ghofrani, H. Ardeschir

AU - Grünig, Ekkehard

AU - Halank, Michael

AU - Held, Matthias

AU - Kaemmerer, Harald

AU - Klose, Hans

AU - Kovacs, Gabor

AU - Konstantinides, Stavros

AU - Lang, Irene M.

AU - Lange, Tobias J.

AU - Leuchte, Hanno

AU - Mayer, Eckhard

AU - Olschewski, Andrea

AU - Olschewski, Horst

AU - Olsson, Karen M.

AU - Opitz, Christian

AU - Schermuly, Ralph T.

AU - Seeger, Werner

AU - Wilkens, Heinrike

AU - Hoeper, Marius M.

PY - 2019/9/26

Y1 - 2019/9/26

N2 - The ESC/ERS guidelines (published at the end of 2015) and other international recommendations defined pulmonary hypertension (PH) by an invasively measured mean pulmonary arterial pressure (mPAP) ≥25mmHg at rest. At the 6 th World Symposium on Pulmonary Hypertension in Nice a modification of this hemodynamic definition in the sense of lowering the threshold to >20mmHg was proposed. A pulmonary vascular resistance (PVR) ≥3 Wood units (WU) is additionally required for the diagnosis of pre-capillary PH. This modification must be critically reviewed with regard to the underlying rationale and possible consequences. Therefore, a detailed explanation is required. In particular, it must be made clear that this change currently has no influence on the evidence-based and approval-compliant prescription of drugs for the targeted therapy of pulmonary arterial hypertension (PAH).

AB - The ESC/ERS guidelines (published at the end of 2015) and other international recommendations defined pulmonary hypertension (PH) by an invasively measured mean pulmonary arterial pressure (mPAP) ≥25mmHg at rest. At the 6 th World Symposium on Pulmonary Hypertension in Nice a modification of this hemodynamic definition in the sense of lowering the threshold to >20mmHg was proposed. A pulmonary vascular resistance (PVR) ≥3 Wood units (WU) is additionally required for the diagnosis of pre-capillary PH. This modification must be critically reviewed with regard to the underlying rationale and possible consequences. Therefore, a detailed explanation is required. In particular, it must be made clear that this change currently has no influence on the evidence-based and approval-compliant prescription of drugs for the targeted therapy of pulmonary arterial hypertension (PAH).

KW - hemodynamic definition

KW - prognosis

KW - pulmonary hypertension

UR - https://www.scopus.com/pages/publications/85072718154

U2 - 10.1055/a-0918-3772

DO - 10.1055/a-0918-3772

M3 - Artikel in Fachzeitschrift

C2 - 31277079

AN - SCOPUS:85072718154

SN - 0012-0472

VL - 144

SP - 1367

EP - 1372

JO - Deutsche Medizinische Wochenschrift

JF - Deutsche Medizinische Wochenschrift

IS - 19

ER -