Growth Differentiation Factor 15 Is Associated with Platelet Reactivity in Patients with Acute Coronary Syndrome

David Mutschlechner, Maximilian Tscharre, Patricia P. Wadowski, Joseph Pultar, Constantin Weikert, Silvia Lee, Beate Eichelberger, Simon Panzer, Thomas Perkmann, Thomas Gremmel*

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

Abstract

Bleeding events in patients with acute coronary syndrome (ACS) are a risk factor for adverse outcomes, including mortality. We investigated the association of growth differentiation factor (GDF)-15, an established predictor of bleeding complications, with on-treatment platelet reactivity in ACS patients undergoing coronary stenting receiving prasugrel or ticagrelor. Platelet aggregation was measured by multiple electrode aggregometry (MEA) in response to adenosine diphosphate (ADP), arachidonic acid (AA), thrombin receptor-activating peptide (TRAP, a protease-activated receptor-1 (PAR-1) agonist), AYPGKF (a PAR-4 agonist) and collagen (COL). GDF-15 levels were measured using a commercially available assay. GDF-15 correlated inversely with MEA ADP (r = −0.202, p = 0.004), MEA AA (r = −0.139, p = 0.048) and MEA TRAP (r = −0.190, p = 0.007). After adjustment, GDF-15 was significantly associated with MEA TRAP (β = −0.150, p = 0.044), whereas no significant associations were detectable for the other agonists. Patients with low platelet reactivity in response to ADP had significantly higher GDF-15 levels (p = 0.005). In conclusion, GDF-15 is inversely associated with TRAP-inducible platelet aggregation in ACS patients treated with state-of-the-art antiplatelet therapy and significantly elevated in patients with low platelet reactivity in response to ADP.

Original languageEnglish
Article number1627
JournalJournal of Clinical Medicine
Volume12
Issue number4
DOIs
Publication statusPublished - Feb 2023

Keywords

  • acute coronary syndrome
  • growth differentiation factor 15
  • platelet reactivity
  • prasugrel
  • ticagrelor

ASJC Scopus subject areas

  • General Medicine

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