Follow-up of sustained virological responders with hepatitis C and advanced liver disease after interferon/ribavirin-free treatment

Karin Kozbial, Stephan Moser, Ramona Al-Zoairy, Remy Schwarzer, Christian Datz, Rudolf Stauber, Hermann Laferl, Michael Strasser, Sandra Beinhardt, Albert F Stättermayer, Michael Gschwantler, Heinz Zoller, Andreas Maieron, Ivo Graziadei, Michael Trauner, Petra Steindl-Munda, Harald Hofer, Peter Ferenci

Research output: Journal article (peer-reviewed)Journal article

43 Citations (Scopus)

Abstract

BACKGROUND: The introduction of direct-acting antivirals (DAA) has increased sustained virological response (SVR) rates in patients with advanced liver disease and chronic hepatitis C(CHC)infection. At present, data on clinical outcome and long-term durability of viral eradication after successful DAA therapy are scarce.

AIM: To evaluate the long-term success of viral eradication in patients with advanced fibrosis or cirrhosis treated with DAAs.

METHODS: Five hundred and fifty-one patients with advanced fibrosis (n = 158) or cirrhosis (CPS-A:317,CPS-B/C:76) and SVR after interferon and ribavirin-free DAA therapy treated between October 2013 and April 2016 were studied with a median follow-up of 65.6 (13.0-155.3) weeks. Only patients without hepatocellular carcinoma (HCC) at baseline and without liver transplantation were included.

RESULTS: Twelve patients (2.2%) died during follow-up: the mortality rate was 0.6% in F3, 2.2% in CPS-A and 5.3% in CPS-B/C patients (P = .08). During follow-up 36 patients with cirrhosis (9.1%) developed a liver related event, including 16 with de-novo HCC (4.1%). Seven patients were transplanted at a median of 9.7 (range 3.8-21.7) months after EOT. History of decompensation was significantly associated with liver related events during follow-up (HR 7.9; 95% CI 2.7-22.6; P < .001), and with mortality (HR 5.5; 95% CI 1.5-20.2, P = .01).

CONCLUSIONS: Eradication of HCV by DAA therapy was durable irrespective of the DAA combination used. Most of the cured patients had an excellent long-term clinical prognosis. Nevertheless, the risk of new occurrence of HCC remains worrisome and thus regular surveillance is obligatory even after clinical stabilization and improvement of the patient.

Original languageEnglish
Pages (from-to)1028-1035
Number of pages8
JournalLiver International
Volume38
Issue number6
DOIs
Publication statusPublished - Jun 2018

Keywords

  • Aged
  • Antiviral Agents/therapeutic use
  • Austria
  • Carcinoma, Hepatocellular/complications
  • Female
  • Follow-Up Studies
  • Hepatitis C, Chronic/complications
  • Humans
  • Interferons
  • Liver Cirrhosis/complications
  • Liver Neoplasms/complications
  • Logistic Models
  • Male
  • Middle Aged
  • Ribavirin
  • Sustained Virologic Response
  • interferon-free treatment
  • follow-up
  • sustained virological response
  • cirrhosis

ASJC Scopus subject areas

  • Hepatology

Fingerprint

Dive into the research topics of 'Follow-up of sustained virological responders with hepatitis C and advanced liver disease after interferon/ribavirin-free treatment'. Together they form a unique fingerprint.

Cite this