Feasibility of Blood Glucose Management Using Intra-Arterial Glucose Monitoring in Combination with an Automated Insulin Titration Algorithm in Critically Ill Patients

Julia K Mader, Melanie Motschnig, Verena Theiler-Schwetz, Karin Eibel-Reisz, Alexander C Reisinger, Bettina Lackner, Thomas Augustin, Philipp Eller, Claudia Mirth

Research output: Journal article (peer-reviewed)Journal article

1 Citation (Scopus)

Abstract

Background: This two-center pilot study combined for the first time an intra-arterial glucose sensor with a decision support system for insulin dosing (SGCplus system) in critically ill patients with hyperglycemia. Methods: Twenty-two patients who were equipped with an arterial line and required iv insulin therapy were managed by the SGCplus system during their medical treatment at the intensive care unit. Results: Time to target was 111 ± 195 min (80-150 mg/dL) and 135 ± 267 min (100-160 mg/dL) in the lower and higher glucose target group. Mean blood glucose (BG) was 142 ± 32 mg/dL with seven BG values <70 mg/dL. Mean daily insulin dose was 62 ± 38 U and mean daily carbohydrate intake 148 ± 50 g/day (enteral nutrition) and 102 ± 58 g/day (parenteral nutrition). Acceptance of SGCplus suggestions was high (93%). Conclusions: The SGCplus system can be safely applied in critically ill patients with hyperglycemia and enables good glycemic control.

Original languageEnglish
Pages (from-to)566-574
Number of pages8
JournalDiabetes Technology and Therapeutics
Volume21
Issue number10
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Aged
  • Algorithms
  • Blood Glucose/analysis
  • Critical Care/methods
  • Critical Illness
  • Data Accuracy
  • Diabetes Mellitus/drug therapy
  • Feasibility Studies
  • Female
  • Humans
  • Hypoglycemic Agents/administration & dosage
  • Insulin/administration & dosage
  • Male
  • Middle Aged
  • Pilot Projects
  • Type 2 diabetes
  • Intra-Arterial glucose sensing
  • Critically ill patients
  • Intensive care unit
  • Hyperglycemia
  • Type 1 diabetes
  • Insulin dosing algorithm
  • Sensors

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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