Feasibility of aluminum phantom radiography for osteoporosis detection in postmenopausal women with a fragility fracture of the distal radius compared to DXA and HR-pQCT

Recently, promising results have been reported for detection of osteoporosis with use of an aluminum phantom. Therefore, the aim of this study was to evaluate the feasibility of radiography-based bone mineral density measurement using a graded aluminum phantom. This study included 27 postmenopausal women with a distal radius fracture. Aluminum phantom radiography of the healthy radius was conducted as well as High-resolution peripheral quantitative computed tomography (HR-pQCT) measurement of the ultradistal radius and DXA of the radius, spine and hip. A strong correlation was observed between aluminum phantom radiography based mean Grey Value (mGV) and DXA derived bone mineral density (BMD) especially for the ultradistal radius (rho=0.75; p<0.001). A moderate correlation for the femoral neck (rho=0.61 and p<0.001) between modalities was found. Radius mGV and HR-pQCT derived BMD only showed a moderate correlation (rho=0.48; p<0.09). Aluminum phantom radiography might serve as a cost efficient, highly available, low-radiation dose screening and diagnostic method for osteoporosis additively to DXA-measurements. Especially an application in areas with constrained DXA availability and such as preoperative trauma settings would be beneficial. However further investigation and assessment of specificity and sensitivity is needed. This article is protected by copyright. All rights reserved.