FE-Simulation in der klinischen Osteoporoseforschung: Möglichkeiten und Trends

Translated title of the contribution: Finite element simulations in clinical osteoporosis research

D. H. Pahr*, P. K. Zysset

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

1 Citation (Scopus)


Osteoporosis leads to higher bone fracture risk and is diagnosed by DXA. Unfortunately, DXA is not a perfect surrogate of bone strength and can often not explain the effect of pharmacological treatment. Currently a new methodology to determine bone strength becomes established: the Finite element method (FEM). This universal, widely accepted engineering method allows to diagnose bone fragility and the effect of treatment better than DXA and QCT. The CT-based FE models depend highly on image resolution. In this review, three types of models are presented (μCT, HR-pQCT, QCT) and the results of densitometric and FEM results are compared. In these cases, the FE results were always superior to densitometric ones. In addition, FE allows to determine a biomechanical fracture risk. Nevertheless, this advantage of FEM needs to be considered in the light of higher X-ray dose and service costs associated with CT imaging. In the future, FEM will be widely applied in the clinics, the question is only when and how.

Translated title of the contributionFinite element simulations in clinical osteoporosis research
Original languageGerman
Pages (from-to)7-12
Number of pages6
Issue number1
Publication statusPublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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