Experimental validation of a nonlinear μFE model based on cohesive-frictional plasticity for trabecular bone

J. Schwiedrzik, T. Gross, M. Bina, M. Pretterklieber, P. Zysset, D. Pahr*

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Journal article

37 Citations (Scopus)

Abstract

Trabecular bone is a porous mineralized tissue playing a major load bearing role in the human body. Prediction of age-related and disease-related fractures and the behavior of bone implant systems needs a thorough understanding of its structure-mechanical property relationships, which can be obtained using microcomputed tomography-based finite element modeling. In this study, a nonlinear model for trabecular bone as a cohesive-frictional material was implemented in a large-scale computational framework and validated by comparison of μFE simulations with experimental tests in uniaxial tension and compression. A good correspondence of stiffness and yield points between simulations and experiments was found for a wide range of bone volume fraction and degree of anisotropy in both tension and compression using a non-calibrated, average set of material parameters. These results demonstrate the ability of the model to capture the effects leading to failure of bone for three anatomical sites and several donors, which may be used to determine the apparent behavior of trabecular bone and its evolution with age, disease, and treatment in the future.

Original languageEnglish
Article numbere02739
JournalInternational Journal for Numerical Methods in Biomedical Engineering
Volume32
Issue number4
DOIs
Publication statusPublished - 01 Apr 2016
Externally publishedYes

Keywords

  • Cohesive-frictional plasticity
  • Experimental validation
  • Parallel computing
  • Trabecular bone
  • Uniaxial compression/tension
  • μFE

ASJC Scopus subject areas

  • Software
  • Biomedical Engineering
  • Modeling and Simulation
  • Molecular Biology
  • Computational Theory and Mathematics
  • Applied Mathematics

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