Efficacy and safety of ibandronate in the treatment of hypercalcemia of malignancy: a randomized multicentric comparison to pamidronate

M Pecherstorfer, E U Steinhauer, R Rizzoli, M Wetterwald, B Bergström

Research output: Journal article (peer-reviewed)Journal article

73 Citations (Scopus)


GOALS: To compare the efficacy and safety of ibandronate and pamidronate in patients with hypercalcemia of malignancy (HCM).

PATIENTS AND METHODS: Seventy-two patients with HCM [albumin-corrected serum calcium (CSC) >2.7 mmol/l] were treated with a single infusion of ibandronate (2 or 4 mg) or pamidronate (15, 30, 60, or 90 mg) on day 0. The dose was dependent on the severity of hypercalcemia (baseline CSC level). CSC was assessed daily until day 4, then at intervals until day 28. The primary endpoint was lowering of CSC at day 4. Secondary endpoints included the number of patients responding and time to re-increase following response.

MAIN RESULTS: Using the CSC baseline approach, the most frequently administered doses were 4 mg ibandronate (78.4%) and 60 mg pamidronate (50.0%). Mean lowering of CSC at day 4 was 0.6 mmol/l for ibandronate and 0.41 mmol/l for pamidronate. The 95% confidence interval for the difference ibandronate pamidronate had a lower limit of 0.05 mmol/l, indicating that ibandronate was as effective as pamidronate. The number of patients responding to the two agents was also similar; 76.5% of ibandronate patients and 75.8% of pamidronate patients were rated as responders after the first dose of study medication. The median time to re-increase after response was longer for ibandronate (14 days) than pamidronate (4 days) ( P=0.0303). In the subgroup of 17 patients with high baseline CSC (>3.5 mmol/l), ibandronate appeared to be more effective than pamidronate. The safety profile of both agents was similar.

CONCLUSIONS: Ibandronate is at least as effective as pamidronate in the treatment of HCM. Furthermore, in patients with higher baseline CSC ibandronate appears to be more effective than pamidronate. The duration of response is significantly longer with ibandronate than pamidronate.

Original languageEnglish
Pages (from-to)539-547
Number of pages9
JournalSupportive Care in Cancer
Issue number8
Publication statusPublished - 01 Aug 2003
Externally publishedYes


  • Administration, Oral
  • Aged
  • Anti-Inflammatory Agents/administration & dosage
  • Bone Resorption
  • Diphosphonates/administration & dosage
  • Female
  • Humans
  • Hypercalcemia/drug therapy
  • Ibandronic Acid
  • Male
  • Middle Aged
  • Neoplasms/complications
  • Pamidronate
  • Treatment Outcome
  • Bisphosphonate
  • Malignancy
  • Hypercalcemia
  • Ibandronate

ASJC Scopus subject areas

  • Oncology


Dive into the research topics of 'Efficacy and safety of ibandronate in the treatment of hypercalcemia of malignancy: a randomized multicentric comparison to pamidronate'. Together they form a unique fingerprint.

Cite this