Deviations From the Ideal Plasma Volume and Isolated Tricuspid Valve Surgery-Paving the Way for New Risk Stratification Parameters

Ena Hasimbegovic; Marco Russo; Martin Andreas; Paul Werner; Iuliana Coti; Dominik Wiedemann; Alfred Kocher; Günther Laufer; Benedikt S Hofer; Markus Mach

doi:10.3389/fcvm.2022.849972

Deviations From the Ideal Plasma Volume and Isolated Tricuspid Valve Surgery-Paving the Way for New Risk Stratification Parameters

Ena Hasimbegovic
, Marco Russo
, Martin Andreas
, Paul Werner
, Iuliana Coti
, Dominik Wiedemann
, Alfred Kocher
, Günther Laufer
, Benedikt S Hofer
, Markus Mach

Research output: Journal article (peer-reviewed) › Journal article

Abstract

BACKGROUND: Congestion and plasma volume expansion are important features of heart failure, whose prognostic significance has been investigated in a range of surgical and non-surgical settings. The aim of this study was to evaluate the value of the estimated plasma volume status (ePVS) in patients undergoing isolated tricuspid valve surgery.

METHODS: This study included patients who underwent isolated tricuspid valve surgery at the Vienna General Hospital (Austria) between July 2008 and November 2018. The PVS cut-off was calculated using ROC analysis and Youden's Index.

RESULTS: Eighty eight patients (median age: 58 [IQR: 35-70] years; 44.3% male; 75.6% NYHA III/IV; median EuroSCORE II 2.65 [IQR: 1.70-5.10]; 33.0% endocarditis-related regurgitation; 60.2% isolated repair; 39.8% isolated replacement) were included in this study. Patients who died within 1 year following surgery had significantly higher baseline ePVS values than survivors (median ePVS 5.29 [IQR: -1.55-13.55] vs. -3.68 [IQR: -10.92-4.22]; p = 0.005). During a median actuarial follow-up of 3.02 (IQR: 0.36-6.80) years, patients with a preoperative ePVS ≥ -4.17 had a significantly increased mortality (log-rank p = 0.006).

CONCLUSIONS: ePVS is an easily obtainable risk parameter for patients undergoing isolated tricuspid valve surgery capable of predicting mid- and long-term outcomes after isolated tricuspid valve surgery.

Original language	English
Article number	849972
Pages (from-to)	849972
Journal	Frontiers in Cardiovascular Medicine
Volume	9
DOIs	https://doi.org/10.3389/fcvm.2022.849972
Publication status	Published - 25 Mar 2022
Externally published	Yes

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10.3389/fcvm.2022.849972

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Hasimbegovic, E., Russo, M., Andreas, M., Werner, P., Coti, I., Wiedemann, D., Kocher, A., Laufer, G., Hofer, B. S., & Mach, M. (2022). Deviations From the Ideal Plasma Volume and Isolated Tricuspid Valve Surgery-Paving the Way for New Risk Stratification Parameters. Frontiers in Cardiovascular Medicine, 9, 849972. Article 849972. https://doi.org/10.3389/fcvm.2022.849972

@article{222b677550c1472b94e83b5032ef2e56,

title = "Deviations From the Ideal Plasma Volume and Isolated Tricuspid Valve Surgery-Paving the Way for New Risk Stratification Parameters",

abstract = "BACKGROUND: Congestion and plasma volume expansion are important features of heart failure, whose prognostic significance has been investigated in a range of surgical and non-surgical settings. The aim of this study was to evaluate the value of the estimated plasma volume status (ePVS) in patients undergoing isolated tricuspid valve surgery.METHODS: This study included patients who underwent isolated tricuspid valve surgery at the Vienna General Hospital (Austria) between July 2008 and November 2018. The PVS cut-off was calculated using ROC analysis and Youden's Index.RESULTS: Eighty eight patients (median age: 58 [IQR: 35-70] years; 44.3\% male; 75.6\% NYHA III/IV; median EuroSCORE II 2.65 [IQR: 1.70-5.10]; 33.0\% endocarditis-related regurgitation; 60.2\% isolated repair; 39.8\% isolated replacement) were included in this study. Patients who died within 1 year following surgery had significantly higher baseline ePVS values than survivors (median ePVS 5.29 [IQR: -1.55-13.55] vs. -3.68 [IQR: -10.92-4.22]; p = 0.005). During a median actuarial follow-up of 3.02 (IQR: 0.36-6.80) years, patients with a preoperative ePVS ≥ -4.17 had a significantly increased mortality (log-rank p = 0.006).CONCLUSIONS: ePVS is an easily obtainable risk parameter for patients undergoing isolated tricuspid valve surgery capable of predicting mid- and long-term outcomes after isolated tricuspid valve surgery.",

author = "Ena Hasimbegovic and Marco Russo and Martin Andreas and Paul Werner and Iuliana Coti and Dominik Wiedemann and Alfred Kocher and G{\"u}nther Laufer and Hofer, \{Benedikt S\} and Markus Mach",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Hasimbegovic, Russo, Andreas, Werner, Coti, Wiedemann, Kocher, Laufer, Hofer and Mach.",

year = "2022",

month = mar,

day = "25",

doi = "10.3389/fcvm.2022.849972",

language = "English",

volume = "9",

pages = "849972",

journal = "Frontiers in Cardiovascular Medicine",

issn = "2297-055X",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Deviations From the Ideal Plasma Volume and Isolated Tricuspid Valve Surgery-Paving the Way for New Risk Stratification Parameters

AU - Hasimbegovic, Ena

AU - Russo, Marco

AU - Andreas, Martin

AU - Werner, Paul

AU - Coti, Iuliana

AU - Wiedemann, Dominik

AU - Kocher, Alfred

AU - Laufer, Günther

AU - Hofer, Benedikt S

AU - Mach, Markus

PY - 2022/3/25

Y1 - 2022/3/25

N2 - BACKGROUND: Congestion and plasma volume expansion are important features of heart failure, whose prognostic significance has been investigated in a range of surgical and non-surgical settings. The aim of this study was to evaluate the value of the estimated plasma volume status (ePVS) in patients undergoing isolated tricuspid valve surgery.METHODS: This study included patients who underwent isolated tricuspid valve surgery at the Vienna General Hospital (Austria) between July 2008 and November 2018. The PVS cut-off was calculated using ROC analysis and Youden's Index.RESULTS: Eighty eight patients (median age: 58 [IQR: 35-70] years; 44.3% male; 75.6% NYHA III/IV; median EuroSCORE II 2.65 [IQR: 1.70-5.10]; 33.0% endocarditis-related regurgitation; 60.2% isolated repair; 39.8% isolated replacement) were included in this study. Patients who died within 1 year following surgery had significantly higher baseline ePVS values than survivors (median ePVS 5.29 [IQR: -1.55-13.55] vs. -3.68 [IQR: -10.92-4.22]; p = 0.005). During a median actuarial follow-up of 3.02 (IQR: 0.36-6.80) years, patients with a preoperative ePVS ≥ -4.17 had a significantly increased mortality (log-rank p = 0.006).CONCLUSIONS: ePVS is an easily obtainable risk parameter for patients undergoing isolated tricuspid valve surgery capable of predicting mid- and long-term outcomes after isolated tricuspid valve surgery.

AB - BACKGROUND: Congestion and plasma volume expansion are important features of heart failure, whose prognostic significance has been investigated in a range of surgical and non-surgical settings. The aim of this study was to evaluate the value of the estimated plasma volume status (ePVS) in patients undergoing isolated tricuspid valve surgery.METHODS: This study included patients who underwent isolated tricuspid valve surgery at the Vienna General Hospital (Austria) between July 2008 and November 2018. The PVS cut-off was calculated using ROC analysis and Youden's Index.RESULTS: Eighty eight patients (median age: 58 [IQR: 35-70] years; 44.3% male; 75.6% NYHA III/IV; median EuroSCORE II 2.65 [IQR: 1.70-5.10]; 33.0% endocarditis-related regurgitation; 60.2% isolated repair; 39.8% isolated replacement) were included in this study. Patients who died within 1 year following surgery had significantly higher baseline ePVS values than survivors (median ePVS 5.29 [IQR: -1.55-13.55] vs. -3.68 [IQR: -10.92-4.22]; p = 0.005). During a median actuarial follow-up of 3.02 (IQR: 0.36-6.80) years, patients with a preoperative ePVS ≥ -4.17 had a significantly increased mortality (log-rank p = 0.006).CONCLUSIONS: ePVS is an easily obtainable risk parameter for patients undergoing isolated tricuspid valve surgery capable of predicting mid- and long-term outcomes after isolated tricuspid valve surgery.

UR - https://www.scopus.com/pages/publications/85138561539

U2 - 10.3389/fcvm.2022.849972

DO - 10.3389/fcvm.2022.849972

M3 - Journal article

C2 - 35402525

SN - 2297-055X

VL - 9

SP - 849972

JO - Frontiers in Cardiovascular Medicine

JF - Frontiers in Cardiovascular Medicine

M1 - 849972

ER -

Deviations From the Ideal Plasma Volume and Isolated Tricuspid Valve Surgery-Paving the Way for New Risk Stratification Parameters

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