TY - JOUR
T1 - Determinants of immunoglobulin G responses to respiratory syncytial virus and rhinovirus in children and adults
AU - Guillien, Alicia
AU - Niespodziana, Katarzyna
AU - Mauclin, Marion
AU - Boudier, Anne
AU - Varraso, Raphäelle
AU - Leynaert, Bénédicte
AU - Dumas, Orianne
AU - Le Moual, Nicole
AU - Schlederer, Thomas
AU - Bajic, Maja
AU - Borochova, Kristina
AU - Errhalt, Peter
AU - Vernet, Raphaël
AU - Nadif, Rachel
AU - Bousquet, Jean
AU - Bouzigon, Emmanuelle
AU - Valenta, Rudolf
AU - Siroux, Valérie
N1 - Publisher Copyright:
Copyright © 2024 Guillien, Niespodziana, Mauclin, Boudier, Varraso, Leynaert, Dumas, Le Moual, Schlederer, Bajic, Borochova, Errhalt, Vernet, Nadif, Bousquet, Bouzigon, Valenta and Siroux.
PY - 2024/3/4
Y1 - 2024/3/4
N2 - INTRODUCTION: Exposure to respiratory viruses is a significant cause of morbidity and affects virus-specific antibody levels. Little is known about determinants associated with immune response to these viruses. We aimed to investigate the determinants of respiratory syncytial virus (RSV)- and rhinovirus (RV)- specific IgG responses in both children and adults.METHODS: The study is based on the EGEA cohort, composed of 530 samples of children in EGEA1 (1991-95) and 1241 samples of adults in EGEA2 (2003-07). Cumulative RV-specific IgG levels (species A, B and C) and IgG levels to RSV-G protein were measured by using micro-array technoloy. Multiple linear mixed models (random effect to account for familial dependence) were performed to assess associations between age, sex, body mass index (BMI), tobacco smoke exposure and season of blood sampling with RSV-and RV-specific IgG levels.RESULTS: In children (11.1 ± 2.8 years old, 57% boys), higher RV-specific IgG levels were associated with older age (only for RV-B), female sex and lower BMI, while only older age was associated with higher RSV-specific IgG levels. In adults (43.5 ± 16.7 years old, 48% men), younger age, female sex, lower BMI, active smoking and all seasons except summer were associated with higher RV-specific IgG levels. Older age, active smoking and all seasons except summer were associated with higher RSV-specific IgG levels.CONCLUSION: Personal and seasonal determinants of RSV- and RV-specific IgG levels seem to vary according to the respiratory virus type and between children and adults, suggesting different patterns of responses along the life course.
AB - INTRODUCTION: Exposure to respiratory viruses is a significant cause of morbidity and affects virus-specific antibody levels. Little is known about determinants associated with immune response to these viruses. We aimed to investigate the determinants of respiratory syncytial virus (RSV)- and rhinovirus (RV)- specific IgG responses in both children and adults.METHODS: The study is based on the EGEA cohort, composed of 530 samples of children in EGEA1 (1991-95) and 1241 samples of adults in EGEA2 (2003-07). Cumulative RV-specific IgG levels (species A, B and C) and IgG levels to RSV-G protein were measured by using micro-array technoloy. Multiple linear mixed models (random effect to account for familial dependence) were performed to assess associations between age, sex, body mass index (BMI), tobacco smoke exposure and season of blood sampling with RSV-and RV-specific IgG levels.RESULTS: In children (11.1 ± 2.8 years old, 57% boys), higher RV-specific IgG levels were associated with older age (only for RV-B), female sex and lower BMI, while only older age was associated with higher RSV-specific IgG levels. In adults (43.5 ± 16.7 years old, 48% men), younger age, female sex, lower BMI, active smoking and all seasons except summer were associated with higher RV-specific IgG levels. Older age, active smoking and all seasons except summer were associated with higher RSV-specific IgG levels.CONCLUSION: Personal and seasonal determinants of RSV- and RV-specific IgG levels seem to vary according to the respiratory virus type and between children and adults, suggesting different patterns of responses along the life course.
KW - Male
KW - Child
KW - Adult
KW - Humans
KW - Female
KW - Adolescent
KW - Middle Aged
KW - Rhinovirus
KW - Respiratory Syncytial Virus Infections
KW - Immunoglobulin G
KW - Respiratory Syncytial Virus, Human
KW - Viruses
KW - Enterovirus Infections
KW - Antibodies, Viral
UR - http://www.scopus.com/inward/record.url?scp=85188118235&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2024.1355214
DO - 10.3389/fimmu.2024.1355214
M3 - Journal article
C2 - 38500884
VL - 15
SP - 1355214
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1355214
ER -