Computer-based three-dimensional visualization of developmental gene expression

J Streicher, M A Donat, B Strauss, R Spörle, K Schughart, G B Müller

Research output: Journal article (peer-reviewed)Journal article

73 Citations (Scopus)


A broad understanding of the relationship between gene activation, pattern formation and morphogenesis will require adequate tools for three- dimensional and, perhaps four-dimensional, representation and analysis of molecular developmental processes. We present a novel, computer-based method for the 3D visualization of embryonic gene expression and morphological structures from serial sections. The information from these automatically aligned 3D reconstructions exceeds that from single-section and whole-mount visualizations of in situ hybridizations. In addition, these 3D models of gene-expression patterns can become a central component of a future developmental database designed for the collection and presentation of digitized, morphological and gene-expression data. This work is accompanied by a web site (

Translated title of the contributionComputergestützte dreidimensionale Visualisierung der Genexpression in der Entwicklung
Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalNature Genetics
Issue number2
Publication statusPublished - Jun 2000
Externally publishedYes


  • Anatomy, Cross-Sectional/methods
  • Animals
  • Automation
  • Computer Simulation
  • Databases, Factual
  • Embryo, Mammalian/anatomy & histology
  • Embryonic and Fetal Development
  • Gene Expression Profiling/methods
  • Gene Expression Regulation, Developmental
  • Genetic Markers/genetics
  • Image Processing, Computer-Assisted/methods
  • In Situ Hybridization/methods
  • Internet
  • Mice
  • Morphogenesis/genetics
  • Organ Specificity
  • Pattern Recognition, Automated
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Software
  • Transcriptional Activation/genetics

ASJC Scopus subject areas

  • Genetics


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