Compatibility of Meropenem with Different Commercial Peritoneal Dialysis Solutions

Martin Wiesholzer, Alexandra Winter, Manuel Kussmann, Markus Zeitlinger, Petra Pichler, Heinz Burgmann, Gottfried Reznicek, Wolfgang Poeppl

Research output: Journal article (peer-reviewed)Journal article

4 Citations (Scopus)

Abstract

♦ BACKGROUND: Intraperitoneal administration of antimicrobial agents is recommended for the treatment of peritoneal dialysis (PD)-related peritonitis. For home-based antimicrobial therapy it is common to supply patients with PD fluid bags with admixed antibiotic. Thus, the compatibility of meropenem with different PD fluids (PDFs), namely Extraneal, Physioneal 1.36% and Physioneal 2.27% (all Baxter Healthcare Corp., Deerfield, IL, USA), was investigated under varying storage conditions. ♦ METHODS: Meropenem (Venus Pharma, Werne, Germany) was stored at 6°C and 25°C over 14 days and at 37°C over 24 hours. Drug concentration over time was determined using high performance liquid chromatography, drug activity by a diffusion disk method, diluent stability by visual inspection and drug adsorption was calculated. Blank PD fluids and deionized water were used as comparator solutions. ♦ RESULTS: Compared to water, the stability of meropenem was minimally lower in Extraneal but markedly reduced in both Physioneal solutions. No significant drug adsorption was detected for any PDF investigated. ♦ CONCLUSIONS: Meropenem is stable and compatible with Extraneal and might be stored for up to a week at refrigeration temperature (6°C). A loss of ~20% of meropenem after 2 days at room temperature should be considered. Mixed Physioneal appears not suitable for storage at any temperature after meropenem has been admixed. A considerable drug degradation due to the warming up to body temperature through heating plates should further be taken into account in clinical practice.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalPeritoneal Dialysis International
Volume37
Issue number1
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Anti-Bacterial Agents/chemistry
  • Dialysis Solutions/chemistry
  • Drug Incompatibility
  • Drug Stability
  • Drug Storage
  • Humans
  • Meropenem
  • Peritoneal Dialysis/adverse effects
  • Peritonitis/drug therapy
  • Sensitivity and Specificity
  • Thienamycins/chemistry

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