Compatibility of ciprofloxacin with commercial peritoneal dialysis solutions

Manuel Kussmann, Alexander Ferth, Markus Obermüller, Petra Pichler, Markus Zeitlinger, Martin Wiesholzer, Heinz Burgmann, Wolfgang Poeppl, Gottfried Reznicek

Research output: Journal article (peer-reviewed)Journal article

7 Citations (Scopus)

Abstract

Intraperitoneal administration of antibiotics together with peritoneal dialysis fluids (PDFs) remains the preferable route for treatment of peritoneal dialysis-related peritonitis. For home based therapy, antibiotic-containing PDFs are stored for up to two weeks and warmed up to body-temperature before administration. The present study investigated the compatibility of ciprofloxacin with five commercial PDFs at refrigeration-temperature, room-temperature and body-temperature. Ciprofloxacin concentrations were determined using high-performance liquid chromatography. Drug-diluent stability was evaluated by measurement of pH-values and visual inspection at each sampling point. The antimicrobial activity of ciprofloxacin was assessed by an E. coli disk diffusion method. Ciprofloxacin was stable at refrigeration-temperature and body-temperature in all PDFs evaluated over the whole study period of 14 days and 24 hours, respectively. At room-temperature, in contrast, ciprofloxacin demonstrated only limited stability in particular when tested in mixed Physioneal. Except for Physioneal 1.36%, no relevant drug adsorption was observed and the antimicrobial activity of ciprofloxacin was found to be preserved in each PDF at each storage condition investigated. Intraperitoneal ciprofloxacin might be used for inpatient and home based therapy of peritoneal dialysis-related peritonitis and no compensatory dose adjustment is needed when stored for up to two weeks at refrigeration-temperature before use.

Original languageEnglish
Article number6512
Pages (from-to)6512
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 01 Dec 2019

Keywords

  • Anti-Bacterial Agents/chemistry
  • Biocompatible Materials/chemistry
  • Chromatography, High Pressure Liquid
  • Ciprofloxacin/chemistry
  • Dialysis Solutions/chemistry
  • Drug Stability
  • Escherichia coli/drug effects
  • Humans
  • Hydrogen-Ion Concentration
  • Peritoneal Dialysis/adverse effects
  • Peritonitis/drug therapy
  • Temperature

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