Compatibility of aztreonam in four commercial peritoneal dialysis fluids

Selma Tobudic, Isabella Prager, Manuel Kussmann, Markus Obermüller, Martin Ursli, Markus Zeitlinger, Martin Wiesholzer, Heinz Burgmann, Wolfgang Poeppl, Gottfried Reznicek

Research output: Journal article (peer-reviewed)Journal article

3 Citations (Scopus)


The preferable route for treatment of peritoneal dialysis related peritonitis remains the intraperitoneal administration of antibiotics admixed to peritoneal dialysis fluids. It is important to know whether the administered drug is compatible with the PD fluids and its container. In the present study the compatibility of aztreonam with four commercial PDFs at storing temperatures and duration representative for storing conditions in the clinical settings was investigated. Aztreonam concentrations were determined using high-performance liquid chromatography. The antimicrobial activity of aztreonam was evaluated using an E. coli diffusion disk inhibition assay and P. aeruginosa time-kill curves. In Extraneal evaluated at 6 °C, 25 °C and 37 °C aztreonam was stable over the whole study period of 14 days and 24 hours, respectively. In Physioneal and Nutrineal aztreonam was stable at 6 °C for up to 14 days. Antimicrobial activity was retained in all PD fluids over the whole study period. Aztreonam remained stable and was compatible with the PD fluids, particularly with Extraneal or Nutrineal, and no compensatory dose adjustment is needed when stored for up to 14 days at refrigeration temperature before use.

Original languageEnglish
Article number1788
Pages (from-to)1788
JournalScientific Reports
Issue number1
Publication statusPublished - 01 Dec 2020


  • Anti-Bacterial Agents/administration & dosage
  • Aztreonam/administration & dosage
  • Dialysis Solutions/chemistry
  • Drug Administration Routes
  • Humans
  • Peritoneal Dialysis/adverse effects
  • Peritonitis/drug therapy


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