TY - JOUR
T1 - Comparative fMRI and MEG localization of cortical sensorimotor function
T2 - Bimodal mapping supports motor area reorganization in glioma patients
AU - Zimmermann, Max
AU - Rössler, Karl
AU - Kaltenhäuser, Martin
AU - Grummich, Peter
AU - Brandner, Nadja
AU - Buchfelder, Michael
AU - Dörfler, Arnd
AU - Kölble, Konrad
AU - Stadlbauer, Andreas
N1 - Publisher Copyright:
© 2019 Zimmermann et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2019/3
Y1 - 2019/3
N2 - INTRODUCTION: Preoperative functional mapping in the vicinity of brain lesion is of high importance for avoiding complications in surgical management. However, space-occupying lesions may lead to functional reorganization or decreased BOLD activity.METHODS: Therefore in 13 patients with cerebral gliomas or brain arterio-venous malformations/ hemangioma fMRI- and MEG-based cortical localizations of motor and somatosensory cortical activation pattern were compared in order to investigate their congruency.RESULTS: Localization of cortical sensorimotor areas with fMRI and MEG showed good congruency with a mean spatial distance of around 10 mm, with differences depending on the localization method. The smallest mean differences for the centroids were found for MEF with MNE 8 mm and SEF with sLORETA 8 mm. Primary motor area (M1) reorganization was found in 5 of 12 patients in fMRI and confirmed with MEG data. In these 5 patients with M1-reorganization the distance between the border of the fMRI-based cortical M1-localization and the tumor border on T1w MR images varied between 0-4 mm, which was significant (P = 0.025) different to the distance in glioma patients without M1-reorganization (5-26 mm).CONCLUSION: Our multimodal preoperative mapping approach combining fMRI and MEG reveals a high degree of spatial congruence and provided high evidence for the presence of motor cortex reorganization.
AB - INTRODUCTION: Preoperative functional mapping in the vicinity of brain lesion is of high importance for avoiding complications in surgical management. However, space-occupying lesions may lead to functional reorganization or decreased BOLD activity.METHODS: Therefore in 13 patients with cerebral gliomas or brain arterio-venous malformations/ hemangioma fMRI- and MEG-based cortical localizations of motor and somatosensory cortical activation pattern were compared in order to investigate their congruency.RESULTS: Localization of cortical sensorimotor areas with fMRI and MEG showed good congruency with a mean spatial distance of around 10 mm, with differences depending on the localization method. The smallest mean differences for the centroids were found for MEF with MNE 8 mm and SEF with sLORETA 8 mm. Primary motor area (M1) reorganization was found in 5 of 12 patients in fMRI and confirmed with MEG data. In these 5 patients with M1-reorganization the distance between the border of the fMRI-based cortical M1-localization and the tumor border on T1w MR images varied between 0-4 mm, which was significant (P = 0.025) different to the distance in glioma patients without M1-reorganization (5-26 mm).CONCLUSION: Our multimodal preoperative mapping approach combining fMRI and MEG reveals a high degree of spatial congruence and provided high evidence for the presence of motor cortex reorganization.
KW - Adult
KW - Aged
KW - Brain Mapping/methods
KW - Brain Neoplasms/physiopathology
KW - Female
KW - Glioma/physiopathology
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Magnetoencephalography/methods
KW - Male
KW - Middle Aged
KW - Motor Cortex/physiopathology
KW - Neuronal Plasticity/physiology
KW - Somatosensory Cortex/physiopathology
UR - http://www.scopus.com/inward/record.url?scp=85062643578&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0213371
DO - 10.1371/journal.pone.0213371
M3 - Journal article
C2 - 30845241
SN - 1932-6203
VL - 14
SP - e0213371
JO - PLoS ONE
JF - PLoS ONE
IS - 3
M1 - e0213371
ER -