Clearance of Selected Plasma Cytokines with Continuous Veno-Venous Hemodialysis Using Ultraflux EMiC2 versus Ultraflux AV1000S

Tanja Eichhorn, Jens Hartmann, Stephan Harm, Ingrid Linsberger, Franz König, Gerhard Valicek, Georg Miestinger, Christoph Hörmann, Viktoria Weber

Research output: Journal article (peer-reviewed)Journal article

11 Citations (Scopus)

Abstract

BACKGROUND: High cutoff hemofilters might support the restoration of immune homeostasis in systemic inflammation by depleting inflammatory mediators from the circulation.

METHODS: Interleukin (IL)-6, IL-8, IL-10, and tumor necrosis factor-alpha depletion was assessed in 30 sepsis patients with acute renal failure using continuous veno-venous hemodialysis with high cutoff versus standard filters (CVVHD-HCO vs. CVVHD-STD) over 48 h.

RESULTS: The transfer of IL-6 and IL-8 was significantly higher for CVVHD-HCO, as shown by increased IL-6 and IL-8 effluent concentrations. The mean plasma cytokine concentrations decreased over time for all cytokines without detectable differences for the treatment modalities. No transfer of albumin was observed for either of the filters. C-reactive protein remained stable over time and did not differ between CVVHD-HCO and CVVHD-STD, while procalcitonin decreased significantly over 48 h for both treatment modalities.

CONCLUSION: CVVHD-HCO achieved enhanced removal of IL-6 and IL-8 as compared to CVVHD-STD, without differentially reducing plasma cytokine levels.

Original languageEnglish
Pages (from-to)260-266
Number of pages7
JournalBlood Purification
Volume44
Issue number4
DOIs
Publication statusPublished - 01 Dec 2017

Keywords

  • C-Reactive Protein/metabolism
  • Cytokines/blood
  • Female
  • Humans
  • Male
  • Renal Dialysis
  • Sepsis/blood

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