Circulating Myostatin Levels Decrease Transiently after Implantation of a Hip Hemi-Arthroplasty

Katharina Kerschan-Schindl, Thomas M Tiefenböck, Ursula Föger-Samwald, Stephan Payr, Stephan Frenzel, Rodrig Marculescu, Andreas Gleiss, Kambiz Sarahrudi, Peter Pietschmann

Research output: Journal article (peer-reviewed)Journal article


INTRODUCTION: Muscle and bone metabolism are both important for the healing of fractures and the regeneration of injured muscle tissue. The aim of this investigation was to evaluate myostatin and other regulating factors in patients with hip fractures who underwent hemi-arthroplasty.

METHODS: Serum levels of myostatin (MSTN), follistatin (FSTN), dickkopf-1 (Dkk1), and periostin (PSTN) as well as markers of bone turnover were evaluated in patients with hip fractures before surgery and twice in the 2 weeks after surgery. These parameters were also evaluated in age- and gender-matched subjects without major musculoskeletal injury.

RESULTS: MSTN was transiently reduced; its opponent FSTN was transiently increased. Dkk1, the negative regulator of bone mass, and PSTN, a marker of subperiosteal bone formation, increased after surgery. With regard to markers of bone turnover, resorption was elevated during the entire period of observation whereas the early bone formation marker N-terminal propeptide of type I collagen was elevated 12 days after surgery.

CONCLUSIONS: Unexpectedly, MSTN, a negative regulator of muscle growth, was reduced after surgery compared with before surgery. As musculoskeletal markers are altered during bone healing, they do not reflect general bone metabolism after fracture or joint arthroplasty. This is important because many elderly patients receive treatment for osteoporosis.

Original languageEnglish
Pages (from-to)393-400
Number of pages8
Issue number4
Publication statusPublished - 01 Jul 2020
Externally publishedYes


  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Hip
  • Austria
  • Biomarkers/blood
  • Bone Morphogenetic Proteins/blood
  • Bone Remodeling/physiology
  • Case-Control Studies
  • Cell Adhesion Molecules/blood
  • Female
  • Follistatin/blood
  • Hemiarthroplasty
  • Hip Fractures/blood
  • Humans
  • Intercellular Signaling Peptides and Proteins/blood
  • Myostatin/blood
  • Osteogenesis/physiology
  • Prospective Studies


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