Caveolin-1 as a potential new therapeutic target in multiple myeloma

Klaus Podar, Kenneth C Anderson

Research output: Journal article (peer-reviewed)Review article

27 Citations (Scopus)

Abstract

Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalCancer Letters
Volume233
Issue number1
DOIs
Publication statusPublished - 20 Feb 2006
Externally publishedYes

Keywords

  • Animals
  • Caveolae/chemistry
  • Caveolin 1/antagonists & inhibitors
  • Cholesterol/biosynthesis
  • Drug Delivery Systems
  • Humans
  • Multiple Myeloma/drug therapy
  • Phosphatidylinositol 3-Kinases/physiology
  • Vascular Endothelial Growth Factor A/physiology

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