Abstract
Caveolae are specialized flask-shaped lipid rafts enriched in cholesterol, sphingolipids, and structural marker proteins termed caveolins. Caveolins are highly conserved hairpin loop-shaped, oligomeric proteins of 22-24 kDa. Besides the plasma cell membrane, caveolins are also present in mitochondria, the endoplasmatic reticulum, the Golgi/trans-Golgi network, and secretory vesicles. They play a critical role in normal vesicular transport, cholesterol homeostasis, and signal transduction. Conversely, dysregulation of caveolin-1 has been associated with several human diseases including multiple myeloma, an incurable malignancy characterized by excess monoclonal plasma cells within the bone marrow. In this mini-review, we characterize the functional role of caveolin-1 in multiple myeloma, and present the preclinical rationale for novel potential therapeutic approaches targeting caveolin-1 in multiple myeloma.
| Original language | English |
|---|---|
| Pages (from-to) | 10-15 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 233 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 20 Feb 2006 |
| Externally published | Yes |
Keywords
- Animals
- Caveolae/chemistry
- Caveolin 1/antagonists & inhibitors
- Cholesterol/biosynthesis
- Drug Delivery Systems
- Humans
- Multiple Myeloma/drug therapy
- Phosphatidylinositol 3-Kinases/physiology
- Vascular Endothelial Growth Factor A/physiology