Carbon ion radiotherapy in the management of the tumors of the peripheral nervous system

Viviana Vitolo; Maria Rosaria Fiore; Amelia Barcellini; Barbara Vischioni; Alberto Iannalfi; Angelica Facoetti; Piero Fossati; Maria Bonora; Sara Ronchi; Emma D’Ippolito; Rachele Petrucci; Gisela Viselner; Mario Ciocca; Lorenzo Preda; Francesca Valvo; Roberto Orecchia

doi:10.21873/anticanres.13193

Carbon ion radiotherapy in the management of the tumors of the peripheral nervous system

Viviana Vitolo
, Maria Rosaria Fiore
, Amelia Barcellini
, Barbara Vischioni
, Alberto Iannalfi
, Angelica Facoetti^*
, Piero Fossati
, Maria Bonora
, Sara Ronchi
, Emma D’Ippolito
, Rachele Petrucci
, Gisela Viselner
, Mario Ciocca
, Lorenzo Preda
, Francesca Valvo
, Roberto Orecchia

^*Corresponding author for this work

Research output: Journal article (peer-reviewed) › Journal article

11 Citations (Scopus)

Abstract

Background/Aim: Malignant peripheral nerve sheaths tumors (MPNST) are rare, highly aggressive and radioresistant tumors of soft tissue. Carbon ion radiotherapy (CIRT) seems to be an attractive treatment option when surgery is not possible or refused by the patient. The aim of this study was to report our preliminary results (outcomes and toxicity) of CIRT in the treatment of MPNSTs. Patients and Methods: Our study retrospectively analyzed 13 patients (median age=54 years; range=23-72 years) with MPNST treated with CIRT for a median total dose of 73.6 Gy (relative biological effectiveness) (range=70.4-76.8 Gy) between 2013 and 2016. Results: Six local progressions were recorded, with a median local progression-free survival of 23.2 months (range=2.2-45.4 months). Acute toxicities were mild. Late toxicity of grade 2 or more was noted in two patients. Conclusion: CIRT yielded good local control with a low rate of acute and late toxicities.

Original language	English
Pages (from-to)	909-913
Number of pages	5
Journal	Anticancer Research
Volume	39
Issue number	2
DOIs	https://doi.org/10.21873/anticanres.13193
Publication status	Published - Feb 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Carbon ion radiotherapy
MPNST
Radiation therapy
Tumors of the peripheral nervous system

ASJC Scopus subject areas

Oncology
Cancer Research

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10.21873/anticanres.13193

Cite this

Vitolo, V., Fiore, M. R., Barcellini, A., Vischioni, B., Iannalfi, A., Facoetti, A., Fossati, P., Bonora, M., Ronchi, S., D’Ippolito, E., Petrucci, R., Viselner, G., Ciocca, M., Preda, L., Valvo, F., & Orecchia, R. (2019). Carbon ion radiotherapy in the management of the tumors of the peripheral nervous system. Anticancer Research, 39(2), 909-913. https://doi.org/10.21873/anticanres.13193

@article{9ff23880dc064a26af8840698515c76d,

title = "Carbon ion radiotherapy in the management of the tumors of the peripheral nervous system",

abstract = "Background/Aim: Malignant peripheral nerve sheaths tumors (MPNST) are rare, highly aggressive and radioresistant tumors of soft tissue. Carbon ion radiotherapy (CIRT) seems to be an attractive treatment option when surgery is not possible or refused by the patient. The aim of this study was to report our preliminary results (outcomes and toxicity) of CIRT in the treatment of MPNSTs. Patients and Methods: Our study retrospectively analyzed 13 patients (median age=54 years; range=23-72 years) with MPNST treated with CIRT for a median total dose of 73.6 Gy (relative biological effectiveness) (range=70.4-76.8 Gy) between 2013 and 2016. Results: Six local progressions were recorded, with a median local progression-free survival of 23.2 months (range=2.2-45.4 months). Acute toxicities were mild. Late toxicity of grade 2 or more was noted in two patients. Conclusion: CIRT yielded good local control with a low rate of acute and late toxicities.",

keywords = "Carbon ion radiotherapy, MPNST, Radiation therapy, Tumors of the peripheral nervous system",

author = "Viviana Vitolo and Fiore, \{Maria Rosaria\} and Amelia Barcellini and Barbara Vischioni and Alberto Iannalfi and Angelica Facoetti and Piero Fossati and Maria Bonora and Sara Ronchi and Emma D{\textquoteright}Ippolito and Rachele Petrucci and Gisela Viselner and Mario Ciocca and Lorenzo Preda and Francesca Valvo and Roberto Orecchia",

year = "2019",

month = feb,

doi = "10.21873/anticanres.13193",

language = "English",

volume = "39",

pages = "909--913",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "2",

}

Vitolo, V, Fiore, MR, Barcellini, A, Vischioni, B, Iannalfi, A, Facoetti, A, Fossati, P, Bonora, M, Ronchi, S, D’Ippolito, E, Petrucci, R, Viselner, G, Ciocca, M, Preda, L, Valvo, F & Orecchia, R 2019, 'Carbon ion radiotherapy in the management of the tumors of the peripheral nervous system', Anticancer Research, vol. 39, no. 2, pp. 909-913. https://doi.org/10.21873/anticanres.13193

TY - JOUR

T1 - Carbon ion radiotherapy in the management of the tumors of the peripheral nervous system

AU - Vitolo, Viviana

AU - Fiore, Maria Rosaria

AU - Barcellini, Amelia

AU - Vischioni, Barbara

AU - Iannalfi, Alberto

AU - Facoetti, Angelica

AU - Fossati, Piero

AU - Bonora, Maria

AU - Ronchi, Sara

AU - D’Ippolito, Emma

AU - Petrucci, Rachele

AU - Viselner, Gisela

AU - Ciocca, Mario

AU - Preda, Lorenzo

AU - Valvo, Francesca

AU - Orecchia, Roberto

PY - 2019/2

Y1 - 2019/2

N2 - Background/Aim: Malignant peripheral nerve sheaths tumors (MPNST) are rare, highly aggressive and radioresistant tumors of soft tissue. Carbon ion radiotherapy (CIRT) seems to be an attractive treatment option when surgery is not possible or refused by the patient. The aim of this study was to report our preliminary results (outcomes and toxicity) of CIRT in the treatment of MPNSTs. Patients and Methods: Our study retrospectively analyzed 13 patients (median age=54 years; range=23-72 years) with MPNST treated with CIRT for a median total dose of 73.6 Gy (relative biological effectiveness) (range=70.4-76.8 Gy) between 2013 and 2016. Results: Six local progressions were recorded, with a median local progression-free survival of 23.2 months (range=2.2-45.4 months). Acute toxicities were mild. Late toxicity of grade 2 or more was noted in two patients. Conclusion: CIRT yielded good local control with a low rate of acute and late toxicities.

AB - Background/Aim: Malignant peripheral nerve sheaths tumors (MPNST) are rare, highly aggressive and radioresistant tumors of soft tissue. Carbon ion radiotherapy (CIRT) seems to be an attractive treatment option when surgery is not possible or refused by the patient. The aim of this study was to report our preliminary results (outcomes and toxicity) of CIRT in the treatment of MPNSTs. Patients and Methods: Our study retrospectively analyzed 13 patients (median age=54 years; range=23-72 years) with MPNST treated with CIRT for a median total dose of 73.6 Gy (relative biological effectiveness) (range=70.4-76.8 Gy) between 2013 and 2016. Results: Six local progressions were recorded, with a median local progression-free survival of 23.2 months (range=2.2-45.4 months). Acute toxicities were mild. Late toxicity of grade 2 or more was noted in two patients. Conclusion: CIRT yielded good local control with a low rate of acute and late toxicities.

KW - Carbon ion radiotherapy

KW - MPNST

KW - Radiation therapy

KW - Tumors of the peripheral nervous system

UR - https://www.scopus.com/pages/publications/85060992700

U2 - 10.21873/anticanres.13193

DO - 10.21873/anticanres.13193

M3 - Journal article

C2 - 30711975

AN - SCOPUS:85060992700

SN - 0250-7005

VL - 39

SP - 909

EP - 913

JO - Anticancer Research

JF - Anticancer Research

IS - 2

ER -

Carbon ion radiotherapy in the management of the tumors of the peripheral nervous system

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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