Cancer vaccines inducing antibody production: More pros than cons

Erika Jensen-Jarolim*, Josef Singer

*Corresponding author for this work

Research output: Journal article (peer-reviewed)Review article

15 Citations (Scopus)


To date, passive immunotherapy with monoclonal antibodies is a well-established option in clinical oncology. By contrast, anticancer Vaccines are less advanced, with the exception of successfully applied prophylactic vaccines against oncogenic virus infections. The creation of therapeutic vaccines is still a great challenge mostly due to the self-nature of tumor antigens. Therapeutic vaccines may be based on patient-specific material including pulsed effector cells, or tumor-associated antigens and derivatives thereof, such as peptides, mimotopes and nucleic acids. The latter represents a more universal approach, which would set an ideal economic framework resulting in broad patient access. In this article we focus on cancer vaccines for antibody production, in particular mimotope vaccines. The collected evidence suggests that they will open up new treatment options in minimal residual disease and early stage disease.

Original languageEnglish
Pages (from-to)1281-1289
Number of pages9
JournalExpert Review of Vaccines
Issue number9
Publication statusPublished - Sept 2011
Externally publishedYes


  • active/passive immunotherapy
  • antibody therapy
  • cancer
  • DNA
  • IgE
  • mimotope
  • passive
  • Treg
  • tumor vaccine

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery


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