TY - CHAP
T1 - Bone Turnover Markers
AU - Kerschan-Schindl, Katharina
AU - Föger-Samwald, Ursula
AU - Pietschmann, Peter
N1 - Publisher Copyright:
© Springer International Publishing AG 2017.
PY - 2017/5/24
Y1 - 2017/5/24
N2 - Bone is a very active tissue that is constantly remodeled in order to adapt to mechanic or metabolic requirements. Since disturbances in bone remodeling may result in relevant skeletal diseases, there is great interest in tools to assess bone remodeling for scientific and clinical applications. Bone turnover markers (BTMs) are among these tools; this chapter presents established markers of bone resorption and bone formation and also selected novel markers. For each marker the biochemical background will be described; in addition you will learn about non-pathological and pathological conditions that lead to alterations of the levels of BTMs. Finally, strengths and weaknesses of the BTMs – especially with regard to their potential clinical applications – will be discussed.
AB - Bone is a very active tissue that is constantly remodeled in order to adapt to mechanic or metabolic requirements. Since disturbances in bone remodeling may result in relevant skeletal diseases, there is great interest in tools to assess bone remodeling for scientific and clinical applications. Bone turnover markers (BTMs) are among these tools; this chapter presents established markers of bone resorption and bone formation and also selected novel markers. For each marker the biochemical background will be described; in addition you will learn about non-pathological and pathological conditions that lead to alterations of the levels of BTMs. Finally, strengths and weaknesses of the BTMs – especially with regard to their potential clinical applications – will be discussed.
UR - https://www.scopus.com/pages/publications/105038639946
U2 - 10.1007/978-3-319-58955-8_4
DO - 10.1007/978-3-319-58955-8_4
M3 - Chapter in book/report
T3 - Principles of Bone and Joint Research
SP - 55
EP - 66
BT - Bone Turnover Markers
ER -