TY - JOUR
T1 - Bioimpedance Spectroscopy Reveals Important Association of Fluid Status and T1 -Mapping by Cardiovascular Magnetic Resonance
AU - Donà, Carolina
AU - Nitsche, Christian
AU - Anegg, Oliver
AU - Poschner, Thomas
AU - Koschutnik, Matthias
AU - Duca, Franz
AU - Aschauer, Stefan
AU - Dannenberg, Varius
AU - Schneider, Matthias
AU - Schoenbauer, Robert
AU - Beitzke, Dietrich
AU - Loewe, Christian
AU - Hengstenberg, Christian
AU - Mascherbauer, Julia
AU - Kammerlander, Andreas
N1 - Publisher Copyright:
© 2022 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
PY - 2022/12
Y1 - 2022/12
N2 - BACKGROUND: Extracellular matrix expansion is a key pathophysiologic feature in heart failure and can be quantified noninvasively by cardiac magnetic resonance T1 -mapping. Free water within the interstitial space of the myocardium, however, may also alter T1 -mapping results.PURPOSE: To investigate the association between systemic fluid status and T1 -mapping by cardiac magnetic resonance.STUDY TYPE: Prospective, observational single-center study.POPULATION: Two-hundred eighty-five consecutive patients (44.4% female, 70.0 ± 14.9 years old) scheduled for cardiac MR due to various cardiac diseases.SEQUENCE AND FIELD STRENGTH: 1.5-T scanner (Avanto Fit, Siemens Healthineers, Erlangen, Germany). For T1 -mapping, electrocardiographically triggered modified-Look-Locker inversion (MOLLI) recovery sequence using a 5(3)3 prototype on a short-axis mid-cavity slice and with a four-chamber view was performed.ASSESSMENTS: MR parameters including native myocardial T1 -times using MOLLI and extracellular volume (MR-ECV) were assessed, and additionally, we performed bioimpedance analysis (BIA). Furthermore, demographic data and comorbidities were assessed.STATISTICS: Wilcoxon's rank-sum test, chi-square tests, and for correlation analysis, Pearson's correlation coefficients were used. Regression analyses were performed to investigate the association between patients' fluid status and T1 -mapping results. A P-value <0.05 was considered statistically significant.RESULTS: The mixed cohort presented with a mean overhydration (OH) of +0.2 ± 2.4 liters, as determined by BIA. By MR, native T1 -times were 1038 ± 51 msec and MR-ECV was 31 ± 9%. In the multivariable regression analysis, only OH was significantly associated with MR-ECV (adj. beta: 0.711; 95% CI: 0.28 to 1.14) along with male sex (adj. beta: 2.529; 95% CI: 0.51 to 4.55). In linear as well as multivariable analysis, only OH was significantly associated with native T1 times (adj. beta: 3.750; 95% CI: 1.27 to 6.23).CONCLUSION: T1 -times and MR-ECV were significantly associated with the degree of OH on BIA measurement. These effects were independent from age, sex, body mass index, and hematocrit. Patients' volume status may thus be an important factor when T1 -time and MR-ECV values are interpreted.LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 3.
AB - BACKGROUND: Extracellular matrix expansion is a key pathophysiologic feature in heart failure and can be quantified noninvasively by cardiac magnetic resonance T1 -mapping. Free water within the interstitial space of the myocardium, however, may also alter T1 -mapping results.PURPOSE: To investigate the association between systemic fluid status and T1 -mapping by cardiac magnetic resonance.STUDY TYPE: Prospective, observational single-center study.POPULATION: Two-hundred eighty-five consecutive patients (44.4% female, 70.0 ± 14.9 years old) scheduled for cardiac MR due to various cardiac diseases.SEQUENCE AND FIELD STRENGTH: 1.5-T scanner (Avanto Fit, Siemens Healthineers, Erlangen, Germany). For T1 -mapping, electrocardiographically triggered modified-Look-Locker inversion (MOLLI) recovery sequence using a 5(3)3 prototype on a short-axis mid-cavity slice and with a four-chamber view was performed.ASSESSMENTS: MR parameters including native myocardial T1 -times using MOLLI and extracellular volume (MR-ECV) were assessed, and additionally, we performed bioimpedance analysis (BIA). Furthermore, demographic data and comorbidities were assessed.STATISTICS: Wilcoxon's rank-sum test, chi-square tests, and for correlation analysis, Pearson's correlation coefficients were used. Regression analyses were performed to investigate the association between patients' fluid status and T1 -mapping results. A P-value <0.05 was considered statistically significant.RESULTS: The mixed cohort presented with a mean overhydration (OH) of +0.2 ± 2.4 liters, as determined by BIA. By MR, native T1 -times were 1038 ± 51 msec and MR-ECV was 31 ± 9%. In the multivariable regression analysis, only OH was significantly associated with MR-ECV (adj. beta: 0.711; 95% CI: 0.28 to 1.14) along with male sex (adj. beta: 2.529; 95% CI: 0.51 to 4.55). In linear as well as multivariable analysis, only OH was significantly associated with native T1 times (adj. beta: 3.750; 95% CI: 1.27 to 6.23).CONCLUSION: T1 -times and MR-ECV were significantly associated with the degree of OH on BIA measurement. These effects were independent from age, sex, body mass index, and hematocrit. Patients' volume status may thus be an important factor when T1 -time and MR-ECV values are interpreted.LEVEL OF EVIDENCE: 2 TECHNICAL EFFICACY STAGE: 3.
KW - T -mapping
KW - bioimpedance spectroscopy
KW - cardiovascular magnetic resonance imaging
KW - fluid status
KW - overhydration
KW - Heart
KW - Predictive Value of Tests
KW - Reproducibility of Results
KW - Prospective Studies
KW - Magnetic Resonance Spectroscopy
KW - Humans
KW - Middle Aged
KW - Magnetic Resonance Imaging/methods
KW - Male
KW - Contrast Media
KW - Myocardium/pathology
KW - Aged, 80 and over
KW - Heart Failure
KW - Female
KW - Aged
UR - http://www.scopus.com/inward/record.url?scp=85127366126&partnerID=8YFLogxK
U2 - 10.1002/jmri.28159
DO - 10.1002/jmri.28159
M3 - Journal article
C2 - 35352420
SN - 1053-1807
VL - 56
SP - 1671
EP - 1679
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
IS - 6
ER -