Arterial stiffness in acute COVID-19 and potential associations with clinical outcome

S Schnaubelt; J Oppenauer; D Tihanyi; M Mueller; E Maldonado-Gonzalez; S Zejnilovic; H Haslacher; T Perkmann; R Strassl; S Anders; T Stefenelli; S Zehetmayer; R Koppensteiner; H Domanovits; O Schlager

doi:10.1111/joim.13275

Arterial stiffness in acute COVID-19 and potential associations with clinical outcome

S Schnaubelt
, J Oppenauer
, D Tihanyi
, M Mueller
, E Maldonado-Gonzalez
, S Zejnilovic
, H Haslacher
, T Perkmann
, R Strassl
, S Anders
, T Stefenelli
, S Zehetmayer
, R Koppensteiner
, H Domanovits
, O Schlager

Research output: Journal article (peer-reviewed) › Journal article

76 Citations (Scopus)

Abstract

BACKGROUND: Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.

METHODS: This case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral pulse wave velocities (cfPWV) of acutely ill patients with and without COVID-19.

RESULTS: Twenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], P = 0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β = 3.164, P = 0.004) and baPWV (β = 3.532, P = 0.003). PWV values were higher in nonsurvivors. In survivors, PWV correlated with length of hospital stay.

CONCLUSION: COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.

Original language	English
Pages (from-to)	437-443
Number of pages	7
Journal	Journal of Internal Medicine
Volume	290
Issue number	2
DOIs	https://doi.org/10.1111/joim.13275
Publication status	Published - Aug 2021
Externally published	Yes

Keywords

Aged
Aged, 80 and over
Brachial Artery/physiopathology
COVID-19/mortality
Carotid Arteries/physiopathology
Case-Control Studies
Female
Femoral Artery/physiopathology
Humans
Length of Stay
Male
Pulse Wave Analysis
Survivors
Vascular Stiffness/physiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/joim.13275

Cite this

Schnaubelt, S., Oppenauer, J., Tihanyi, D., Mueller, M., Maldonado-Gonzalez, E., Zejnilovic, S., Haslacher, H., Perkmann, T., Strassl, R., Anders, S., Stefenelli, T., Zehetmayer, S., Koppensteiner, R., Domanovits, H., & Schlager, O. (2021). Arterial stiffness in acute COVID-19 and potential associations with clinical outcome. Journal of Internal Medicine, 290(2), 437-443. https://doi.org/10.1111/joim.13275

@article{e5c8dfe4c20f459888ff9179659d414e,

title = "Arterial stiffness in acute COVID-19 and potential associations with clinical outcome",

abstract = "BACKGROUND: Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.METHODS: This case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral pulse wave velocities (cfPWV) of acutely ill patients with and without COVID-19.RESULTS: Twenty-two COVID-19 patients (50\% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], P = 0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β = 3.164, P = 0.004) and baPWV (β = 3.532, P = 0.003). PWV values were higher in nonsurvivors. In survivors, PWV correlated with length of hospital stay.CONCLUSION: COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.",

keywords = "Aged, Aged, 80 and over, Brachial Artery/physiopathology, COVID-19/mortality, Carotid Arteries/physiopathology, Case-Control Studies, Female, Femoral Artery/physiopathology, Humans, Length of Stay, Male, Pulse Wave Analysis, Survivors, Vascular Stiffness/physiology",

author = "S Schnaubelt and J Oppenauer and D Tihanyi and M Mueller and E Maldonado-Gonzalez and S Zejnilovic and H Haslacher and T Perkmann and R Strassl and S Anders and T Stefenelli and S Zehetmayer and R Koppensteiner and H Domanovits and O Schlager",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors. Journal of Internal Medicine published by John Wiley \& Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.",

year = "2021",

month = aug,

doi = "10.1111/joim.13275",

language = "English",

volume = "290",

pages = "437--443",

journal = "Journal of Internal Medicine",

issn = "0954-6820",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

Schnaubelt, S, Oppenauer, J, Tihanyi, D, Mueller, M, Maldonado-Gonzalez, E, Zejnilovic, S, Haslacher, H, Perkmann, T, Strassl, R, Anders, S, Stefenelli, T, Zehetmayer, S, Koppensteiner, R, Domanovits, H & Schlager, O 2021, 'Arterial stiffness in acute COVID-19 and potential associations with clinical outcome', Journal of Internal Medicine, vol. 290, no. 2, pp. 437-443. https://doi.org/10.1111/joim.13275

TY - JOUR

T1 - Arterial stiffness in acute COVID-19 and potential associations with clinical outcome

AU - Schnaubelt, S

AU - Oppenauer, J

AU - Tihanyi, D

AU - Mueller, M

AU - Maldonado-Gonzalez, E

AU - Zejnilovic, S

AU - Haslacher, H

AU - Perkmann, T

AU - Strassl, R

AU - Anders, S

AU - Stefenelli, T

AU - Zehetmayer, S

AU - Koppensteiner, R

AU - Domanovits, H

AU - Schlager, O

PY - 2021/8

Y1 - 2021/8

N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.METHODS: This case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral pulse wave velocities (cfPWV) of acutely ill patients with and without COVID-19.RESULTS: Twenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], P = 0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β = 3.164, P = 0.004) and baPWV (β = 3.532, P = 0.003). PWV values were higher in nonsurvivors. In survivors, PWV correlated with length of hospital stay.CONCLUSION: COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.

AB - BACKGROUND: Coronavirus disease 2019 (COVID-19) interferes with the vascular endothelium. It is not known whether COVID-19 additionally affects arterial stiffness.METHODS: This case-control study compared brachial-ankle pulse wave (baPWV) and carotid-femoral pulse wave velocities (cfPWV) of acutely ill patients with and without COVID-19.RESULTS: Twenty-two COVID-19 patients (50% females, 77 [67-84] years) were compared with 22 age- and sex-matched controls. In COVID-19 patients, baPWV (19.9 [18.4-21.0] vs. 16.0 [14.2-20.4], P = 0.02) and cfPWV (14.3 [13.4-16.0] vs. 11.0 [9.5-14.6], P = 0.01) were higher than in the controls. In multiple regression analysis, COVID-19 was independently associated with higher cfPWV (β = 3.164, P = 0.004) and baPWV (β = 3.532, P = 0.003). PWV values were higher in nonsurvivors. In survivors, PWV correlated with length of hospital stay.CONCLUSION: COVID-19 appears to be related to an enhanced PWV reflecting an increase in arterial stiffness. Higher PWV might be related to an increased length of hospital stay and mortality.

KW - Aged

KW - Aged, 80 and over

KW - Brachial Artery/physiopathology

KW - COVID-19/mortality

KW - Carotid Arteries/physiopathology

KW - Case-Control Studies

KW - Female

KW - Femoral Artery/physiopathology

KW - Humans

KW - Length of Stay

KW - Male

KW - Pulse Wave Analysis

KW - Survivors

KW - Vascular Stiffness/physiology

UR - https://www.scopus.com/pages/publications/85102829056

U2 - 10.1111/joim.13275

DO - 10.1111/joim.13275

M3 - Journal article

C2 - 33651387

SN - 0954-6820

VL - 290

SP - 437

EP - 443

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

IS - 2

ER -

Arterial stiffness in acute COVID-19 and potential associations with clinical outcome

Abstract

Keywords

UN SDGs

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